A Study of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Gastroesophageal Junction or Gastric Cancer (JACOB)
A Double-Blind, Placebo-Controlled, Randomized, Multicenter Phase III Study Evaluating the Efficacy and Safety of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Patients With HER2-Positive Metastatic Gastroesophageal Junction and Gastric Cancer
Sponsor: Hoffmann-La Roche
A PHASE3 clinical study on Gastric Cancer, this trial is completed. The trial is conducted by Hoffmann-La Roche and has accumulated 24 data snapshots since 2013. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.
Status Flow
Change History
24 versions recorded-
Dec 2025 — Present [monthly]
Completed PHASE3
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Sep 2025 — Dec 2025 [monthly]
Completed PHASE3
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Sep 2024 — Sep 2025 [monthly]
Completed PHASE3
-
Jul 2024 — Sep 2024 [monthly]
Completed PHASE3
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Jan 2021 — Jul 2024 [monthly]
Completed PHASE3
▶ Show 19 earlier versions
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Jul 2020 — Jan 2021 [monthly]
Completed PHASE3
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Feb 2020 — Jul 2020 [monthly]
Completed PHASE3
Status: Active Not Recruiting → Completed
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Jan 2020 — Feb 2020 [monthly]
Active Not Recruiting PHASE3
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Dec 2019 — Jan 2020 [monthly]
Active Not Recruiting PHASE3
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Nov 2019 — Dec 2019 [monthly]
Active Not Recruiting PHASE3
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Aug 2019 — Nov 2019 [monthly]
Active Not Recruiting PHASE3
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May 2019 — Aug 2019 [monthly]
Active Not Recruiting PHASE3
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Feb 2019 — May 2019 [monthly]
Active Not Recruiting PHASE3
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Nov 2018 — Feb 2019 [monthly]
Active Not Recruiting PHASE3
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Aug 2018 — Nov 2018 [monthly]
Active Not Recruiting PHASE3
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Jun 2018 — Aug 2018 [monthly]
Active Not Recruiting PHASE3
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May 2018 — Jun 2018 [monthly]
Active Not Recruiting PHASE3
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Mar 2018 — May 2018 [monthly]
Active Not Recruiting PHASE3
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Dec 2017 — Mar 2018 [monthly]
Active Not Recruiting PHASE3
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Aug 2017 — Dec 2017 [monthly]
Active Not Recruiting PHASE3
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Jun 2017 — Aug 2017 [monthly]
Active Not Recruiting PHASE3
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Apr 2017 — Jun 2017 [monthly]
Active Not Recruiting PHASE3
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Feb 2017 — Apr 2017 [monthly]
Active Not Recruiting PHASE3
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Jan 2017 — Feb 2017 [monthly]
Active Not Recruiting PHASE3
First recorded
Jun 2013
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Hoffmann-La Roche
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Aichi, Japan , Albany, United States , Almaty, Kazakhstan , Amsterdam, Netherlands , Ancona, Italy , Ankara, Turkey (Türkiye) , Antalya, Turkey (Türkiye) , Arequipa, Peru , Badalona, Spain , Bangkok, Thailand and 130 more locations