deltatrials
Recruiting PHASE3 INTERVENTIONAL 1-arm NCT01804686

A Long-term Extension Study of PCI-32765 (Ibrutinib) (CAN3001)

A Phase 3b, Multicenter, Open-label, PCI-32765 (Ibrutinib) Long-term Extension Study

Sponsor: Janssen Research & Development, LLC

Conditions Chronic Graft Versus Host Disease Chronic Lymphocytic Leukemia Diffuse Large B-cell Lymphoma Follicular Lymphoma Mantle Cell Lymphoma Small Lymphocytic Lymphoma Waldenstrom Macroglobulinemia
Interventions Ibrutinib
Updated 89 times since 2017 Last updated: Mar 11, 2026 Started: Sep 9, 2013 Primary completion: Dec 31, 2026 Completion: Aug 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Chronic Graft Versus Host Disease and Chronic Lymphocytic Leukemia and is currently actively recruiting participants. Janssen Research & Development, LLC leads this study, which shows 89 recorded versions since 2013 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Nov 2017 · 2 months · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Mar 2018 · 3 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Oct 2020 · 5 months · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Aug 2023 · 2 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Aug 2025 · 2 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshot~Mar 2026 – present · 5 months · monthly snapshot

Change History

89 versions recorded

  1. Mar 2026 — Present [monthly]

    Recruiting PHASE3

  2. Feb 2026 — Mar 2026 [monthly]

    Recruiting PHASE3

  3. Jan 2026 — Feb 2026 [monthly]

    Recruiting PHASE3

  4. Dec 2025 — Jan 2026 [monthly]

    Recruiting PHASE3

  5. Nov 2025 — Dec 2025 [monthly]

    Recruiting PHASE3

▶ Show 84 earlier versions

  1. Oct 2025 — Nov 2025 [monthly]

    Recruiting PHASE3

  2. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE3

  3. Aug 2025 — Sep 2025 [monthly]

    Recruiting PHASE3

  4. Jun 2025 — Aug 2025 [monthly]

    Recruiting PHASE3

  5. May 2025 — Jun 2025 [monthly]

    Recruiting PHASE3

  6. Apr 2025 — May 2025 [monthly]

    Recruiting PHASE3

  7. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE3

  8. Feb 2025 — Mar 2025 [monthly]

    Recruiting PHASE3

  9. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE3

    Status: Enrolling By Invitation → Recruiting

  10. Nov 2024 — Jan 2025 [monthly]

    Enrolling By Invitation PHASE3

  11. Oct 2024 — Nov 2024 [monthly]

    Enrolling By Invitation PHASE3

  12. Sep 2024 — Oct 2024 [monthly]

    Enrolling By Invitation PHASE3

  13. Aug 2024 — Sep 2024 [monthly]

    Enrolling By Invitation PHASE3

  14. Jul 2024 — Aug 2024 [monthly]

    Enrolling By Invitation PHASE3

  15. Jun 2024 — Jul 2024 [monthly]

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  16. May 2024 — Jun 2024 [monthly]

    Enrolling By Invitation PHASE3

  17. Apr 2024 — May 2024 [monthly]

    Enrolling By Invitation PHASE3

  18. Mar 2024 — Apr 2024 [monthly]

    Enrolling By Invitation PHASE3

  19. Feb 2024 — Mar 2024 [monthly]

    Enrolling By Invitation PHASE3

  20. Jan 2024 — Feb 2024 [monthly]

    Enrolling By Invitation PHASE3

  21. Dec 2023 — Jan 2024 [monthly]

    Enrolling By Invitation PHASE3

  22. Nov 2023 — Dec 2023 [monthly]

    Enrolling By Invitation PHASE3

  23. Oct 2023 — Nov 2023 [monthly]

    Enrolling By Invitation PHASE3

  24. Sep 2023 — Oct 2023 [monthly]

    Enrolling By Invitation PHASE3

  25. Aug 2023 — Sep 2023 [monthly]

    Enrolling By Invitation PHASE3

  26. Jun 2023 — Aug 2023 [monthly]

    Enrolling By Invitation PHASE3

  27. May 2023 — Jun 2023 [monthly]

    Enrolling By Invitation PHASE3

  28. Apr 2023 — May 2023 [monthly]

    Enrolling By Invitation PHASE3

  29. Mar 2023 — Apr 2023 [monthly]

    Enrolling By Invitation PHASE3

  30. Feb 2023 — Mar 2023 [monthly]

    Enrolling By Invitation PHASE3

  31. Jan 2023 — Feb 2023 [monthly]

    Enrolling By Invitation PHASE3

  32. Dec 2022 — Jan 2023 [monthly]

    Enrolling By Invitation PHASE3

  33. Nov 2022 — Dec 2022 [monthly]

    Enrolling By Invitation PHASE3

  34. Sep 2022 — Nov 2022 [monthly]

    Enrolling By Invitation PHASE3

  35. Jul 2022 — Sep 2022 [monthly]

    Enrolling By Invitation PHASE3

  36. Jun 2022 — Jul 2022 [monthly]

    Enrolling By Invitation PHASE3

  37. May 2022 — Jun 2022 [monthly]

    Enrolling By Invitation PHASE3

  38. Apr 2022 — May 2022 [monthly]

    Enrolling By Invitation PHASE3

  39. Mar 2022 — Apr 2022 [monthly]

    Enrolling By Invitation PHASE3

  40. Feb 2022 — Mar 2022 [monthly]

    Enrolling By Invitation PHASE3

  41. Jan 2022 — Feb 2022 [monthly]

    Enrolling By Invitation PHASE3

  42. Dec 2021 — Jan 2022 [monthly]

    Enrolling By Invitation PHASE3

  43. Nov 2021 — Dec 2021 [monthly]

    Enrolling By Invitation PHASE3

  44. Oct 2021 — Nov 2021 [monthly]

    Enrolling By Invitation PHASE3

  45. Sep 2021 — Oct 2021 [monthly]

    Enrolling By Invitation PHASE3

  46. Jun 2021 — Sep 2021 [monthly]

    Enrolling By Invitation PHASE3

  47. May 2021 — Jun 2021 [monthly]

    Enrolling By Invitation PHASE3

  48. Apr 2021 — May 2021 [monthly]

    Enrolling By Invitation PHASE3

  49. Mar 2021 — Apr 2021 [monthly]

    Enrolling By Invitation PHASE3

  50. Feb 2021 — Mar 2021 [monthly]

    Enrolling By Invitation PHASE3

  51. Jan 2021 — Feb 2021 [monthly]

    Enrolling By Invitation PHASE3

  52. Dec 2020 — Jan 2021 [monthly]

    Enrolling By Invitation PHASE3

  53. Oct 2020 — Dec 2020 [monthly]

    Enrolling By Invitation PHASE3

  54. May 2020 — Oct 2020 [monthly]

    Enrolling By Invitation PHASE3

  55. Mar 2020 — May 2020 [monthly]

    Enrolling By Invitation PHASE3

    Status: Recruiting → Enrolling By Invitation

  56. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

    Status: Enrolling By Invitation → Recruiting

  57. Jan 2020 — Feb 2020 [monthly]

    Enrolling By Invitation PHASE3

  58. Nov 2019 — Jan 2020 [monthly]

    Enrolling By Invitation PHASE3

  59. Oct 2019 — Nov 2019 [monthly]

    Enrolling By Invitation PHASE3

  60. Sep 2019 — Oct 2019 [monthly]

    Enrolling By Invitation PHASE3

  61. Jul 2019 — Sep 2019 [monthly]

    Enrolling By Invitation PHASE3

  62. Jun 2019 — Jul 2019 [monthly]

    Enrolling By Invitation PHASE3

  63. May 2019 — Jun 2019 [monthly]

    Enrolling By Invitation PHASE3

  64. Apr 2019 — May 2019 [monthly]

    Enrolling By Invitation PHASE3

  65. Mar 2019 — Apr 2019 [monthly]

    Enrolling By Invitation PHASE3

  66. Feb 2019 — Mar 2019 [monthly]

    Enrolling By Invitation PHASE3

  67. Jan 2019 — Feb 2019 [monthly]

    Enrolling By Invitation PHASE3

  68. Dec 2018 — Jan 2019 [monthly]

    Enrolling By Invitation PHASE3

  69. Nov 2018 — Dec 2018 [monthly]

    Enrolling By Invitation PHASE3

  70. Oct 2018 — Nov 2018 [monthly]

    Enrolling By Invitation PHASE3

  71. Sep 2018 — Oct 2018 [monthly]

    Enrolling By Invitation PHASE3

  72. Aug 2018 — Sep 2018 [monthly]

    Enrolling By Invitation PHASE3

  73. Jul 2018 — Aug 2018 [monthly]

    Enrolling By Invitation PHASE3

  74. Jun 2018 — Jul 2018 [monthly]

    Enrolling By Invitation PHASE3

  75. Mar 2018 — Jun 2018 [monthly]

    Enrolling By Invitation PHASE3

  76. Dec 2017 — Mar 2018 [monthly]

    Enrolling By Invitation PHASE3

  77. Nov 2017 — Dec 2017 [monthly]

    Enrolling By Invitation PHASE3

    Status: Recruiting → Enrolling By Invitation

  78. Sep 2017 — Nov 2017 [monthly]

    Recruiting PHASE3

    Status: Enrolling By Invitation → Recruiting

  79. Aug 2017 — Sep 2017 [monthly]

    Enrolling By Invitation PHASE3

  80. Jun 2017 — Aug 2017 [monthly]

    Enrolling By Invitation PHASE3

  81. May 2017 — Jun 2017 [monthly]

    Enrolling By Invitation PHASE3

  82. Apr 2017 — May 2017 [monthly]

    Enrolling By Invitation PHASE3

  83. Feb 2017 — Apr 2017 [monthly]

    Enrolling By Invitation PHASE3

  84. Jan 2017 — Feb 2017 [monthly]

    Enrolling By Invitation PHASE3

    First recorded

Sep 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Research & Development, LLC
  • Pharmacyclics LLC.
Data source: Janssen Research & Development, LLC

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Adelaide, Australia , Afula, Israel , Amsterdam, Netherlands , Ankara, Turkey (Türkiye) , Ann Arbor, United States , Antwerp, Belgium , Arkhangelsk, Russia , Athens, Greece , Barcelona, Spain , Battle Creek, United States and 148 more locations