deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT01815853

Neoadjuvant Chemoradiotherapy vs. Chemotherapy Followed by Radical Gastrectomy and Adjuvant Chemotherapy for Advanced Gastric Cancer (Neo-CRAG)

A Randomized, Open-Label, Multicenter, Controlled Phase III Trial Comparing Neoadjuvant Chemoradiotherapy Followed by Surgery and Adjuvant Chemotherapy Versus Neoadjuvant Chemotherapy Followed by Surgery and Adjuvant Chemotherapy in Patients With Locally Advanced Gastric Cancer

Sponsor: First Hospital of China Medical University

Conditions Gastric Cancer
Interventions Adjuvant Chemotherapy Neoadjuvant Chemoradiotherapy Neoadjuvant Chemotherapy R0 D2 Gastrectomy
Updated 10 times since 2017 Last updated: Jun 30, 2025 Started: Jun 30, 2013 Primary completion: Jun 30, 2025 Completion: Jun 30, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Gastric Cancer, this trial is completed. The trial is conducted by First Hospital of China Medical University and has accumulated 10 data snapshots since 2013. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Jun 2018 · 17 months · monthly snapshotRecruiting~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshotRecruiting~Sep 2018 – ~Dec 2018 · 3 months · monthly snapshotRecruiting~Dec 2018 – ~Dec 2019 · 12 months · monthly snapshotRecruiting~Dec 2019 – ~Jan 2021 · 13 months · monthly snapshotRecruiting~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshotRecruiting~Oct 2024 – ~Aug 2025 · 10 months · monthly snapshotRecruiting~Aug 2025 – present · 10 months · monthly snapshotCompleted

Change History

10 versions recorded

  1. Aug 2025 — Present [monthly]

    Completed PHASE3

    Status: Recruiting → Completed

  2. Oct 2024 — Aug 2025 [monthly]

    Recruiting PHASE3

  3. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  5. Jan 2021 — Jul 2024 [monthly]

    Recruiting PHASE3

▶ Show 5 earlier versions

  1. Dec 2019 — Jan 2021 [monthly]

    Recruiting PHASE3

  2. Dec 2018 — Dec 2019 [monthly]

    Recruiting PHASE3

  3. Sep 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  4. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  5. Jan 2017 — Jun 2018 [monthly]

    Recruiting PHASE3

    First recorded

Jun 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • First Hospital of China Medical University
  • Guangdong Provincial Hospital of Traditional Chinese Medicine
  • Guangdong Provincial People's Hospital
  • Hangzhou First People's Hospital, School of Medicine, Zhejiang Universiry
  • Liaoning Cancer Hospital & Institute
  • National Clinical Research Center for Cancer/Cancer Hospital
  • Sichuan Cancer Hospital and Research Institute
  • Sun Yat-sen University
  • The Affiliated Hospital of Qingdao University
  • The Affiliated Tumor Hospital of Guangxi Medical University
  • The First Affiliated Hospital of Anhui Medical University
  • Tianjin Medical University Cancer Institute and Hospital
  • Zhejiang Cancer Hospital
Data source: Sun Yat-sen University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations