deltatrials
Completed PHASE4 INTERVENTIONAL 2-arm NCT01842581

The Safety/Efficacy of Rifaximin With/Without Lactulose in Participants With A History of Recurrent Hepatic Encephalopathy

A Multicenter, Randomized, Open-Label, Active-Controlled, Trial to Evaluate the Safety and Efficacy of Rifaximin 550 mg With and Without Lactulose in Subjects With a History of Recurrent Overt Hepatic Encephalopathy

Sponsor: Bausch Health Americas, Inc.

Updated 11 times since 2017 Last updated: Sep 6, 2019 Started: Jan 8, 2013 Primary completion: Dec 17, 2014 Completion: Dec 17, 2014
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT01842581, this PHASE4 trial focuses on Cirrhosis and Hepatic Encephalopathy and remains completed. Sponsored by Bausch Health Americas, Inc., it has been updated 11 times since 2013, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotCompleted~Feb 2017 – ~May 2017 · 3 months · monthly snapshotCompleted~May 2017 – ~Jun 2018 · 13 months · monthly snapshotCompleted~Jun 2018 – ~Jun 2019 · 12 months · monthly snapshotCompleted~Jun 2019 – ~Oct 2019 · 4 months · monthly snapshotCompleted~Oct 2019 – ~Jan 2021 · 15 months · monthly snapshotCompleted~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshotCompleted~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotCompleted~Sep 2025 – present · 12 months · monthly snapshotCompleted

Change History

11 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE4

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE4

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE4

  4. Dec 2021 — Jul 2024 [monthly]

    Completed PHASE4

  5. Jan 2021 — Dec 2021 [monthly]

    Completed PHASE4

Show 6 earlier versions
  1. Oct 2019 — Jan 2021 [monthly]

    Completed PHASE4

  2. Jun 2019 — Oct 2019 [monthly]

    Completed PHASE4

  3. Jun 2018 — Jun 2019 [monthly]

    Completed PHASE4

  4. May 2017 — Jun 2018 [monthly]

    Completed PHASE4

  5. Feb 2017 — May 2017 [monthly]

    Completed PHASE4

  6. Jan 2017 — Feb 2017 [monthly]

    Completed PHASE4

    First recorded

Jan 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bausch Health Americas, Inc.
Data source: Bausch Health Americas, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .