deltatrials
Completed PHASE1 INTERVENTIONAL 2-arm NCT01851733

MRI-Guided Laser Surgery and Doxorubicin Hydrochloride in Treating Patients With Recurrent Glioblastoma Multiforme

A Pilot Study of Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Doxorubicin in the Treatment of Recurrent Glioblastoma Multiforme

Sponsor: The Foundation for Barnes-Jewish Hospital

Conditions Glioblastoma
Interventions Blood draw - dendritic cells Doxorubicin Dynamic Susceptibility Contrast Magnetic Resonance Imaging MRI-guided Laser Heat Ablation (MLA)
Updated 14 times since 2017 Last updated: Aug 26, 2021 Started: Aug 13, 2013 Primary completion: Apr 12, 2018 Completion: May 30, 2018
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Glioblastoma, this trial is completed. The trial is conducted by The Foundation for Barnes-Jewish Hospital and has accumulated 14 data snapshots since 2013. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~Aug 2017 · 4 months · monthly snapshot~Aug 2017 – ~Jun 2018 · 10 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Aug 2019 · 12 months · monthly snapshot~Aug 2019 – ~Feb 2020 · 6 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Jan 2021 · 10 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Jul 2024 · 34 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

14 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  4. Sep 2021 — Jul 2024 [monthly]

    Completed PHASE1

  5. Jan 2021 — Sep 2021 [monthly]

    Completed PHASE1

▶ Show 9 earlier versions

  1. Mar 2020 — Jan 2021 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE1

  3. Aug 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE1

  4. Aug 2018 — Aug 2019 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  5. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  6. Aug 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

  7. Apr 2017 — Aug 2017 [monthly]

    Recruiting PHASE1

    Phase: NA → PHASE1

  8. Feb 2017 — Apr 2017 [monthly]

    Recruiting NA

  9. Jan 2017 — Feb 2017 [monthly]

    Recruiting NA

    First recorded

Aug 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • The Foundation for Barnes-Jewish Hospital
  • Washington University School of Medicine
Data source: Washington University School of Medicine

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations