deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT01880567

Ibrutinib and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or Older Patients With Newly Diagnosed Mantle Cell Lymphoma

A Phase II Study of Ibrutinib Plus Rituximab in Patients With Relapsed/Refractory Mantle Cell Lymphoma or Elderly Patients With Newly Diagnosed MCL

Sponsor: M.D. Anderson Cancer Center

Conditions CCND1 Positive CCND2 Positive CCND3 Positive CD20 Positive Mantle Cell Lymphoma Recurrent Mantle Cell Lymphoma Refractory Mantle Cell Lymphoma
Interventions Ibrutinib Laboratory Biomarker Analysis Rituximab
Updated 25 times since 2017 Last updated: Feb 17, 2026 Started: Jul 15, 2013 Primary completion: Jul 31, 2026 Completion: Jul 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT01880567, this PHASE2 trial focuses on CCND1 Positive and CCND2 Positive and remains ongoing. Sponsored by M.D. Anderson Cancer Center, it has been updated 25 times since 2013, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jul 2017 · 5 months · monthly snapshot~Jul 2017 – ~Jun 2018 · 11 months · monthly snapshot~Jun 2018 – ~Oct 2018 · 4 months · monthly snapshot~Oct 2018 – ~Jul 2019 · 9 months · monthly snapshot~Jul 2019 – ~Nov 2019 · 4 months · monthly snapshot~Nov 2019 – ~Oct 2020 · 11 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Feb 2022 · 12 months · monthly snapshot~Feb 2022 – ~Dec 2022 · 10 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Sep 2023 · 8 months · monthly snapshot~Sep 2023 – ~May 2024 · 8 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Mar 2025 · 59 days · monthly snapshot~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Feb 2026 · 3 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

25 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Nov 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jun 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Mar 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 20 earlier versions

  1. Jan 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

  2. Dec 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  6. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  7. Sep 2023 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  8. Jan 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE2

  9. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE2

  10. Feb 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

  11. Feb 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE2

  12. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE2

  13. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  14. Nov 2019 — Oct 2020 [monthly]

    Recruiting PHASE2

  15. Jul 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  16. Oct 2018 — Jul 2019 [monthly]

    Recruiting PHASE2

  17. Jun 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  18. Jul 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  19. Feb 2017 — Jul 2017 [monthly]

    Recruiting PHASE2

  20. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Jul 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations