deltatrials
Completed PHASE3 INTERVENTIONAL 4-arm NCT01889862

Phase 3 Study to Evaluate the Efficacy & Safety of Self-Administered Injections of BMN165 by Adults With PKU (Prism-2)

A Four-Part, Phase 3, Randomized, Double-Blind, Placebo- Controlled, Four-Arm, Discontinuation Study to Evaluate the Efficacy and Safety of Subcutaneous Injections of BMN 165 Self-Administered by Adults With Phenylketonuria (PKU)

Sponsor: BioMarin Pharmaceutical

Updated 12 times since 2017 Last updated: Apr 29, 2021 Started: Jul 29, 2013 Primary completion: Jan 13, 2016 Completion: Feb 5, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Phenylketonuria (PKU) and is currently completed. BioMarin Pharmaceutical leads this study, which shows 12 recorded versions since 2013 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotActive Not Recruiting~Feb 2017 – ~Dec 2017 · 10 months · monthly snapshotActive Not Recruiting~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshotActive Not Recruiting~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshotActive Not Recruiting~Jun 2018 – ~Aug 2019 · 14 months · monthly snapshotActive Not Recruiting~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshotCompleted~Sep 2019 – ~Jan 2021 · 16 months · monthly snapshotCompleted~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshotCompleted~Jun 2021 – ~Jul 2024 · 37 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotCompleted~Sep 2025 – present · 11 months · monthly snapshotCompleted

Change History

12 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Jun 2021 — Jul 2024 [monthly]

    Completed PHASE3

  5. Jan 2021 — Jun 2021 [monthly]

    Completed PHASE3

Show 7 earlier versions
  1. Sep 2019 — Jan 2021 [monthly]

    Completed PHASE3

  2. Aug 2019 — Sep 2019 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  3. Jun 2018 — Aug 2019 [monthly]

    Active Not Recruiting PHASE3

  4. Jan 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  5. Dec 2017 — Jan 2018 [monthly]

    Active Not Recruiting PHASE3

  6. Feb 2017 — Dec 2017 [monthly]

    Active Not Recruiting PHASE3

  7. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE3

    First recorded

Jul 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • BioMarin Pharmaceutical
Data source: BioMarin Pharmaceutical

For direct contact, visit the study record on ClinicalTrials.gov .