deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT01891812

Nitrous Oxide Analgesia Vaso-occlusive Crisis

Nitrous Oxide for Analgesia in Sickle Cell Vaso-occlusive Crisis

Sponsor: Columbia University

Interventions Nitrous oxide 50%
Updated 12 times since 2017 Last updated: Jan 9, 2026 Started: Nov 12, 2013 Primary completion: Jan 19, 2018 Completion: Jan 19, 2018
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Sickle Cell Disease and Vaso-occlusive Crisis and is currently completed. Columbia University leads this study, which shows 12 recorded versions since 2013 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Jun 2018 · 17 months · monthly snapshotRecruiting~Jun 2018 – ~Feb 2019 · 8 months · monthly snapshotRecruiting~Feb 2019 – ~Nov 2020 · 21 months · monthly snapshotRecruiting~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshotCompleted~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshotCompleted~Sep 2021 – ~Jul 2024 · 34 months · monthly snapshotTerminated~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshotTerminated~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshotTerminated~Sep 2024 – ~Feb 2026 · 17 months · monthly snapshotTerminated~Jan 2026 – present · 3 months · monthly snapshotTerminated~Feb 2026 – present · 55 days · monthly snapshotCompleted~Feb 2026 – present · 55 days · monthly snapshotCompleted

Change History

12 versions recorded
  1. Feb 2026 — Present [monthly]

    Completed PHASE2

  2. Feb 2026 — Present [monthly]

    Completed PHASE2

    Status: TerminatedCompleted

  3. Jan 2026 — Present [monthly]

    Terminated PHASE2

  4. Sep 2024 — Feb 2026 [monthly]

    Terminated PHASE2

  5. Aug 2024 — Sep 2024 [monthly]

    Terminated PHASE2

Show 7 earlier versions
  1. Jul 2024 — Aug 2024 [monthly]

    Terminated PHASE2

  2. Sep 2021 — Jul 2024 [monthly]

    Terminated PHASE2

    Status: CompletedTerminated

  3. Jan 2021 — Sep 2021 [monthly]

    Completed PHASE2

  4. Nov 2020 — Jan 2021 [monthly]

    Completed PHASE2

    Status: RecruitingCompleted

  5. Feb 2019 — Nov 2020 [monthly]

    Recruiting PHASE2

  6. Jun 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  7. Jan 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

    First recorded

Nov 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Columbia University
Data source: Columbia University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations