Phase I/II Study of SGI-110 With Irinotecan Versus Regorafenib or TAS-102 in Metastatic Colorectal Cancer
A Phase I Study of SGI-110 Combined With Irinotecan Followed by a Randomized Phase II Study of SGI-110 Combined With Irinotecan Versus Regorafenib or TAS-102 in Previously Treated Metastatic Colorectal Cancer Patients
Sponsor: Astex Pharmaceuticals, Inc.
A PHASE1/PHASE2 clinical study on Previously Treated Metastatic Colorectal Cancer, this trial is completed. The trial is conducted by Astex Pharmaceuticals, Inc. and has accumulated 12 data snapshots since 2013. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.
Change History
12 versions recorded-
Sep 2024 — Present [monthly]
Completed PHASE1/PHASE2
-
Jul 2024 — Sep 2024 [monthly]
Completed PHASE1/PHASE2
Phase: PHASE1_PHASE2 → PHASE1/PHASE2
-
Jan 2021 — Jul 2024 [monthly]
Completed PHASE1_PHASE2
-
Nov 2020 — Jan 2021 [monthly]
Completed PHASE1_PHASE2
-
Oct 2020 — Nov 2020 [monthly]
Completed PHASE1_PHASE2
Phase: PHASE2 → PHASE1_PHASE2
▶ Show 7 earlier versions
-
Feb 2020 — Oct 2020 [monthly]
Completed PHASE2
Status: Active Not Recruiting → Completed
-
May 2019 — Feb 2020 [monthly]
Active Not Recruiting PHASE2
Status: Recruiting → Active Not Recruiting
-
Oct 2018 — May 2019 [monthly]
Recruiting PHASE2
-
Jun 2018 — Oct 2018 [monthly]
Recruiting PHASE2
-
Feb 2018 — Jun 2018 [monthly]
Recruiting PHASE2
Phase: PHASE1_PHASE2 → PHASE2
-
Feb 2017 — Feb 2018 [monthly]
Recruiting PHASE1_PHASE2
-
Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE1_PHASE2
First recorded
Oct 2013
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Astex Pharmaceuticals, Inc.
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Van Andel Research Institute
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
- • Amsterdam, Netherlands
- • Baltimore, United States
- • Los Angeles, United States
- • New York, United States