deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 1-arm NCT01904136

Natural Killer Cells Before and After Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia

A Phase I/II Clinical Trial of NK Cells Administration to Prevent Disease Relapse for Patient With High-Risk Myeloid Malignancies Undergoing Haploidentical Stem-Cell Transplantation

Sponsor: M.D. Anderson Cancer Center

Conditions Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome Acute Myeloid Leukemia With Gene Mutations Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive Myelodysplastic Syndrome Recurrent Acute Myeloid Leukemia Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive Therapy-Related Acute Myeloid Leukemia de Novo Myelodysplastic Syndrome
Interventions Allogeneic Hematopoietic Stem Cell Transplantation Bone Marrow Transplantation Cyclophosphamide Fludarabine Laboratory Biomarker Analysis Melphalan Mycophenolate Mofetil Natural Killer Cell Therapy Peripheral Blood Stem Cell Transplantation Tacrolimus Total-Body Irradiation
Updated 22 times since 2017 Last updated: Jan 22, 2024 Started: Apr 22, 2014 Primary completion: Feb 28, 2022 Completion: Feb 28, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive and Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome and is currently completed. M.D. Anderson Cancer Center leads this study, which shows 22 recorded versions since 2014 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~Jun 2018 · 14 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Mar 2019 · 3 months · monthly snapshot~Mar 2019 – ~Jun 2019 · 3 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Jan 2020 · 6 months · monthly snapshot~Jan 2020 – ~Jul 2020 · 6 months · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2022 · 13 months · monthly snapshot~Apr 2022 – ~Feb 2024 · 22 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

22 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  3. Feb 2024 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

  4. Apr 2022 — Feb 2024 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

  5. Mar 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

▶ Show 17 earlier versions

  1. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  2. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  3. Jul 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Jan 2020 — Jul 2020 [monthly]

    Recruiting PHASE1_PHASE2

  5. Jul 2019 — Jan 2020 [monthly]

    Recruiting PHASE1_PHASE2

  6. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1_PHASE2

  7. Mar 2019 — Jun 2019 [monthly]

    Recruiting PHASE1_PHASE2

  8. Dec 2018 — Mar 2019 [monthly]

    Recruiting PHASE1_PHASE2

  9. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE1_PHASE2

  10. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE1_PHASE2

  11. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE1_PHASE2

  12. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1_PHASE2

  13. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1_PHASE2

  14. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1_PHASE2

  15. Apr 2017 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  16. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE1_PHASE2

  17. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Apr 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations