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Active Not Recruiting PHASE1 INTERVENTIONAL 1-arm NCT01947023

Dabrafenib and Lapatinib in Treating Patients With Refractory Thyroid Cancer That Cannot Be Removed by Surgery

A Phase 1 Study of Dabrafenib in Combination With Lapatinib in BRAF Mutant Thyroid Cancer

Sponsor: National Cancer Institute (NCI)

Conditions Metastatic Thyroid Gland Carcinoma Unresectable Thyroid Gland Carcinoma
Interventions Biopsy Procedure Biospecimen Collection Computed Tomography Dabrafenib Dabrafenib Mesylate Echocardiography Test Lapatinib Lapatinib Ditosylate Magnetic Resonance Imaging Multigated Acquisition Scan Positron Emission Tomography
Updated 38 times since 2017 Last updated: Nov 4, 2025 Started: Sep 27, 2013 Primary completion: Jun 1, 2026 Completion: Jun 1, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT01947023, this PHASE1 trial focuses on Metastatic Thyroid Gland Carcinoma and Unresectable Thyroid Gland Carcinoma and remains ongoing. Sponsored by National Cancer Institute (NCI), it has been updated 38 times since 2013, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Oct 2017 · 4 months · monthly snapshot~Oct 2017 – ~Apr 2018 · 6 months · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Nov 2018 · 5 months · monthly snapshot~Nov 2018 – ~Mar 2019 · 4 months · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Sep 2021 · 7 months · monthly snapshot~Sep 2021 – ~Mar 2022 · 6 months · monthly snapshot~Mar 2022 – ~May 2022 · 2 months · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Apr 2023 · 7 months · monthly snapshot~Apr 2023 – ~Jan 2024 · 9 months · monthly snapshot~Jan 2024 – ~May 2024 · 4 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Jun 2025 · 7 months · monthly snapshot~Jun 2025 – ~Oct 2025 · 4 months · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – present · 9 months · monthly snapshot

Change History

38 versions recorded

  1. Dec 2025 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Jun 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Nov 2024 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 33 earlier versions

  1. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  3. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Jan 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Apr 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE1

  6. Sep 2022 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1

  7. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  8. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1

  9. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1

  10. Mar 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE1

  11. Sep 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

  12. Feb 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  13. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE1

  14. Aug 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  15. Jun 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE1

  16. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE1

  17. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE1

  18. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE1

  19. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE1

  20. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE1

  21. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE1

  22. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE1

  23. Sep 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE1

  24. Jul 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE1

  25. May 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE1

  26. Mar 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE1

  27. Nov 2018 — Mar 2019 [monthly]

    Active Not Recruiting PHASE1

  28. Jun 2018 — Nov 2018 [monthly]

    Active Not Recruiting PHASE1

  29. Apr 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  30. Oct 2017 — Apr 2018 [monthly]

    Recruiting PHASE1

  31. Jun 2017 — Oct 2017 [monthly]

    Recruiting PHASE1

  32. Feb 2017 — Jun 2017 [monthly]

    Recruiting PHASE1

  33. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Sep 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations