deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT01950234

ACTH in Progressive Forms of MS

Treatment of Progressive Forms of Multiple Sclerosis With Pulsed ACTH (Acthar Gel)

Sponsor: Mallinckrodt

Interventions ACTH Placebo
Updated 15 times since 2017 Last updated: Feb 10, 2025 Started: Apr 17, 2014 Primary completion: Dec 31, 2022 Completion: Dec 31, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

The funding source discontinued financial support for the study.

This PHASE2 trial investigates Primary Progressive Multiple Sclerosis and Progressive Relapsing Multiple Sclerosis and is currently terminated or withdrawn. Mallinckrodt leads this study, which shows 15 recorded versions since 2014 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Apr 2019 · 10 months · monthly snapshot~Apr 2019 – ~Nov 2019 · 7 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jul 2020 · 7 months · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Apr 2022 · 7 months · monthly snapshot~Apr 2022 – ~Sep 2022 · 5 months · monthly snapshot~Sep 2022 – ~Jun 2023 · 9 months · monthly snapshot~Jun 2023 – ~Jul 2024 · 13 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – present · 18 months · monthly snapshot

Change History

15 versions recorded
  1. Mar 2025 — Present [monthly]

    Terminated PHASE2

  2. Sep 2024 — Mar 2025 [monthly]

    Terminated PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  4. Jun 2023 — Jul 2024 [monthly]

    Terminated PHASE2

    Status: Active Not RecruitingTerminated

  5. Sep 2022 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2

Show 10 earlier versions
  1. Apr 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

  3. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  5. Dec 2019 — Jul 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  6. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  7. Apr 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  8. Jun 2018 — Apr 2019 [monthly]

    Recruiting PHASE2

  9. Feb 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  10. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Apr 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Mallinckrodt
  • University of Minnesota
Data source: University of Minnesota

For direct contact, visit the study record on ClinicalTrials.gov .