Completed PHASE2 INTERVENTIONAL 2-arm NCT01958320

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus (PDA:TOLERATE)

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus in Preterm infants-a Multicenter Trial

Sponsor: University of California, San Francisco

Conditions Intestinal Perforation Necrotizing Enterocolitis Patent Ductus Arteriosus Surgery

Interventions NSAID no pharmacologic treatment of the PDA pharmacologic treatment of the PDA

Updated 11 times since 2017 Last updated: Nov 28, 2018 Started: Dec 31, 2013 Primary completion: Jun 30, 2017 Completion: Jun 30, 2017

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Intestinal Perforation and Necrotizing Enterocolitis, this trial is completed. The trial is conducted by University of California, San Francisco and has accumulated 11 data snapshots since 2013. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

11 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2
Jan 2023 — Jul 2024 [monthly]

Completed PHASE2
Dec 2022 — Jan 2023 [monthly]

Completed PHASE2

▶ Show 6 earlier versions

Dec 2021 — Dec 2022 [monthly]

Completed PHASE2
Jan 2021 — Dec 2021 [monthly]

Completed PHASE2
Dec 2018 — Jan 2021 [monthly]

Completed PHASE2
Jun 2018 — Dec 2018 [monthly]

Completed PHASE2

Status: Recruiting → Completed
Feb 2017 — Jun 2018 [monthly]

Recruiting PHASE2
Jan 2017 — Feb 2017 [monthly]

Recruiting PHASE2

First recorded

Dec 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

University of California, San Francisco

Data source: University of California, San Francisco

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Ankara, Turkey (Türkiye) , Baltimore, United States , Chicago, United States , Evanston, United States , Glasgow, United Kingdom , Istanbul, Turkey (Türkiye) , Malatya, Turkey (Türkiye) , Miami, United States , Morristown, United States , New York, United States and 7 more locations