deltatrials
Terminated PHASE2 INTERVENTIONAL 3-arm NCT02023905

Everolimus With and Without Temozolomide in Adult Low Grade Glioma

PI3K/mTOR Pathway Activation Selected Phase II Study of Everolimus (RAD001) With and Without Temozolomide in the Treatment of Adult Patients With Supratentorial Low-Grade Glioma

Sponsor: Novartis

Updated 12 times since 2017 Last updated: Nov 29, 2022 Started: Mar 19, 2014 Primary completion: Sep 30, 2021 Completion: Sep 30, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Sponsor decision

This PHASE2 trial investigates Low Grade Glioma and Mixed Oligoastrocytomas and is currently terminated or withdrawn. Novartis leads this study, which shows 12 recorded versions since 2014 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotRecruiting~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshotRecruiting~Jun 2018 – ~Apr 2019 · 10 months · monthly snapshotRecruiting~Apr 2019 – ~Apr 2020 · 12 months · monthly snapshotActive Not Recruiting~Apr 2020 – ~Aug 2020 · 4 months · monthly snapshotActive Not Recruiting~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshotActive Not Recruiting~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshotActive Not Recruiting~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshotActive Not Recruiting~Dec 2021 – ~Feb 2023 · 14 months · monthly snapshotTerminated~Feb 2023 – ~Jul 2024 · 17 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – present · 24 months · monthly snapshotTerminated

Change History

12 versions recorded
  1. Sep 2024 — Present [monthly]

    Terminated PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  3. Feb 2023 — Jul 2024 [monthly]

    Terminated PHASE2

  4. Dec 2021 — Feb 2023 [monthly]

    Terminated PHASE2

    Status: Active Not RecruitingTerminated

  5. Sep 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE2

Show 7 earlier versions
  1. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  2. Aug 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  3. Apr 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE2

  4. Apr 2019 — Apr 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  5. Jun 2018 — Apr 2019 [monthly]

    Recruiting PHASE2

  6. Feb 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  7. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Mar 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novartis
  • University of California, San Francisco
Data source: University of California, San Francisco

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations