Early-start Exercise Training in Subacute Heart Failure (RE-START)
Early-start Exercise Training After Acute Hemodynamic Decompensation in Patients With Chronic Heart Failure. A Multicenter, Randomized, Controlled Trial on Feasibility and Impact on Functional Capacity, Symptoms and Neurohumoral Activation.
Sponsor: Fondazione Salvatore Maugeri
This NA trial investigates Chronic Heart Failure and Heart Decompensation and is currently ongoing. Fondazione Salvatore Maugeri leads this study, which shows 6 recorded versions since 2013 — indicating limited longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.
Study Description(click to expand)Prescription of aerobic exercise training in stable chronic heart failure patients finds an evidence-based justification in the acknowledged long-term positive effects of aerobic exercise training on both functional capacity and prognosis in this population. In recent time, evidence has accumulated in normal subjects about short-term favorable effects of aerobic exercise training on sympatho-vagal balance and flow-mediated vasodilation, two physiological mechanisms known to be profoundly altered in the setting of acute hemodynamic decompensation of chronic heart failure. The possible extension of aerobic exercise training indication to chronic heart failure patients admitted for recent acute hemodynamic decompensation not stabilized as yet, may thus provide a valuable, low-cost tool to effectively manage such a high-risk and resource-absorbing population.
Prescription of aerobic exercise training in stable chronic heart failure patients finds an evidence-based justification in the acknowledged long-term positive effects of aerobic exercise training on both functional capacity and prognosis in this population. In recent time, evidence has accumulated in normal subjects about short-term favorable effects of aerobic exercise training on sympatho-vagal balance and flow-mediated vasodilation, two physiological mechanisms known to be profoundly altered in the setting of acute hemodynamic decompensation of chronic heart failure. The possible extension of aerobic exercise training indication to chronic heart failure patients admitted for recent acute hemodynamic decompensation not stabilized as yet, may thus provide a valuable, low-cost tool to effectively manage such a high-risk and resource-absorbing population.
Status Flow
Change History
6 versions recorded-
Jan 2026 — Present [monthly]
Unknown NA
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Sep 2025 — Present [monthly]
Unknown NA
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Sep 2024 — Sep 2025 [monthly]
Unknown NA
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Jul 2024 — Sep 2024 [monthly]
Unknown NA
Status: Unknown Status → Unknown
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Jan 2021 — Jul 2024 [monthly]
Unknown Status NA
▶ Show 1 earlier version
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Jan 2017 — Jan 2021 [monthly]
Unknown Status NA
First recorded
Oct 2013
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Fondazione Salvatore Maugeri
For direct contact, visit the study record on ClinicalTrials.gov .