deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 13-arm NCT02057133

A Study of LY2835219 (Abemaciclib) in Combination With Therapies for Breast Cancer That Has Spread

A Phase 1b Study of Abemaciclib in Combination With Therapies for Patients With Metastatic Breast Cancer

Sponsor: Eli Lilly and Company

Conditions Breast Neoplasms
Interventions Anastrozole Endocrine therapy Everolimus Exemestane Fulvestrant LY2835219 LY3023414 Letrozole Loperamide Pertuzumab Tamoxifen Trastuzumab
Updated 28 times since 2017 Last updated: Jan 23, 2026 Started: Mar 10, 2014 Primary completion: Mar 15, 2021 Completion: Dec 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Breast Neoplasms and is currently ongoing. Eli Lilly and Company leads this study, which shows 28 recorded versions since 2014 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2018 · 13 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Apr 2019 · 3 months · monthly snapshot~Apr 2019 – ~Aug 2019 · 4 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Dec 2019 · 3 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~May 2020 · 4 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Mar 2022 · 6 months · monthly snapshot~Mar 2022 – ~Sep 2022 · 6 months · monthly snapshot~Sep 2022 – ~May 2023 · 8 months · monthly snapshot~May 2023 – ~Nov 2023 · 6 months · monthly snapshot~Nov 2023 – ~Apr 2024 · 5 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~May 2025 · 8 months · monthly snapshot~May 2025 – ~Feb 2026 · 9 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

28 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE1

  2. May 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2024 — May 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 23 earlier versions

  1. Nov 2023 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

  2. May 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  4. Mar 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

  6. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  7. Jul 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  8. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE1

  9. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  10. Jan 2020 — May 2020 [monthly]

    Recruiting PHASE1

  11. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  12. Sep 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  13. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  14. Apr 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  15. Jan 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  16. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

  17. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  18. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  19. Aug 2018 — Oct 2018 [monthly]

    Recruiting PHASE1

  20. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  21. May 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

  22. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE1

  23. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Mar 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Eli Lilly and Company
Data source: Eli Lilly and Company

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations