deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT02070458

Ixazomib, Mitoxantrone Hydrochloride, Etoposide, and Intermediate-Dose Cytarabine in Relapsed or Refractory Acute Myeloid Leukemia

A Phase 1 Study of MLN9708 in Combination With MEC (Mitoxantrone, Etoposide, and Intermediate-Dose Cytarabine) for Relapsed/ Refractory Acute Myelogenous Leukemia (AML)

Sponsor: Case Comprehensive Cancer Center

Conditions Recurrent Adult Acute Myeloid Leukemia Refractory Acute Myeloid Leukemia
Interventions cytarabine etoposide ixazomib mitoxantrone hydrochloride
Updated 8 times since 2017 Last updated: Dec 12, 2018 Started: Oct 8, 2014 Primary completion: Mar 17, 2017 Completion: Aug 15, 2017
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02070458, this PHASE1 trial focuses on Recurrent Adult Acute Myeloid Leukemia and Refractory Acute Myeloid Leukemia and remains completed. Sponsored by Case Comprehensive Cancer Center, it has been updated 8 times since 2014, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotRecruiting~Feb 2017 – ~Feb 2018 · 12 months · monthly snapshotActive Not Recruiting~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshotActive Not Recruiting~Jun 2018 – ~Jan 2019 · 7 months · monthly snapshotActive Not Recruiting~Jan 2019 – ~Jan 2021 · 24 months · monthly snapshotCompleted~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – present · 22 months · monthly snapshotCompleted

Change History

8 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE1

  4. Jan 2019 — Jan 2021 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  5. Jun 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE1

▶ Show 3 earlier versions

  1. Feb 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1

  2. Feb 2017 — Feb 2018 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  3. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Oct 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Case Comprehensive Cancer Center
  • National Cancer Institute (NCI)
Data source: Case Comprehensive Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations