deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT02101281

Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye

An Open-label Study Evaluating Safety and Efficacy of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drops at Different Doses in Patients With Dry Eye

Sponsor: Cross Research S.A.

Updated 13 times since 2017 Last updated: Apr 17, 2024 Started: Jan 20, 2014 Primary completion: Jan 31, 2015 Completion: Jan 31, 2015
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Dry Eye Syndrome and is currently completed. Cross Research S.A. leads this study, which shows 13 recorded versions since 2014 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Oct 2017 · 9 months · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Sep 2019 · 15 months · monthly snapshot~Sep 2019 – ~Aug 2020 · 11 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Jan 2023 · 13 months · monthly snapshot~Jan 2023 – ~May 2024 · 16 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

13 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. May 2024 — Jul 2024 [monthly]

    Completed PHASE2

  5. Jan 2023 — May 2024 [monthly]

    Completed PHASE2

Show 8 earlier versions
  1. Dec 2021 — Jan 2023 [monthly]

    Completed PHASE2

  2. Oct 2021 — Dec 2021 [monthly]

    Completed PHASE2

  3. Jan 2021 — Oct 2021 [monthly]

    Completed PHASE2

  4. Aug 2020 — Jan 2021 [monthly]

    Completed PHASE2

  5. Sep 2019 — Aug 2020 [monthly]

    Completed PHASE2

  6. Jun 2018 — Sep 2019 [monthly]

    Completed PHASE2

  7. Oct 2017 — Jun 2018 [monthly]

    Completed PHASE2

  8. Jan 2017 — Oct 2017 [monthly]

    Completed PHASE2

    First recorded

Jan 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Cross Research S.A.
  • Dompé Farmaceutici S.p.A
Data source: Dompé Farmaceutici S.p.A

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations