Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels
Sponsor: Faisal_Karmali@MEEI.HARVARD.EDU
This PHASE4 trial investigates Vestibular and is currently completed. Faisal_Karmali@MEEI.HARVARD.EDU leads this study, which shows 11 recorded versions since 2014 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.
Study Description(click to expand)Adaptation to altered gravity has been of concern from the earliest reports of space motion sickness, through the Apollo exploration era, and into current planning of exploration missions. The proposed research program takes a new approach which could lead to an effective, practical and acceptable protocol for preadapting astronauts to space flight. By using the gravito-inertial alterations possible with centrifugation in different body orientations the investigators will quantify an individual's sensory adaptation capability and use it to predict and to minimize the consequences of movement in any other gravity environment - eventually including weightlessness. The investigators will also study whether a drug (promethazine) affects motion perception and motion sickness.
Adaptation to altered gravity has been of concern from the earliest reports of space motion sickness, through the Apollo exploration era, and into current planning of exploration missions. The proposed research program takes a new approach which could lead to an effective, practical and acceptable protocol for preadapting astronauts to space flight. By using the gravito-inertial alterations possible with centrifugation in different body orientations the investigators will quantify an individual's sensory adaptation capability and use it to predict and to minimize the consequences of movement in any other gravity environment - eventually including weightlessness. The investigators will also study whether a drug (promethazine) affects motion perception and motion sickness.
Status Flow
Change History
11 versions recorded-
Jan 2026 — Present [monthly]
Completed PHASE4
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Sep 2024 — Present [monthly]
Completed PHASE4
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Jul 2024 — Sep 2024 [monthly]
Completed PHASE4
-
Jan 2023 — Jul 2024 [monthly]
Completed PHASE4
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Dec 2022 — Jan 2023 [monthly]
Completed PHASE4
▶ Show 6 earlier versions
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Jan 2021 — Dec 2022 [monthly]
Completed PHASE4
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Jun 2018 — Jan 2021 [monthly]
Completed PHASE4
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Jan 2018 — Jun 2018 [monthly]
Completed PHASE4
Status: Suspended → Completed
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Apr 2017 — Jan 2018 [monthly]
Suspended PHASE4
Status: Completed → Suspended
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Feb 2017 — Apr 2017 [monthly]
Completed PHASE4
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Jan 2017 — Feb 2017 [monthly]
Completed PHASE4
First recorded
Jun 2014
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Faisal_Karmali@MEEI.HARVARD.EDU
- Massachusetts Institute of Technology
- National Space Biomedical Research Institute
For direct contact, visit the study record on ClinicalTrials.gov .