deltatrials
Active Not Recruiting PHASE4 INTERVENTIONAL 2-arm NCT02162849

Reward Sensitivity and Pharmacotherapy for Smoking Cessation

The Effects of Behavioral Counseling Plus Nicotine Replacement Therapy (NRT) or Varenicline on Smoking Cessation Among Smokers High and Low in Intrinsic Reward Sensitivity

Sponsor: M.D. Anderson Cancer Center

Conditions Tobacco Use Cessation
Interventions Counseling Sessions Lab Session Nicotine Patch Placebo Patch Placebo Tablet Questionnaires Saliva Test Varenicline
Updated 19 times since 2017 Last updated: Feb 5, 2026 Started: Dec 14, 2015 Primary completion: Feb 28, 2028 Completion: Feb 28, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02162849, this PHASE4 trial focuses on Tobacco Use Cessation and remains ongoing. Sponsored by M.D. Anderson Cancer Center, it has been updated 19 times since 2015, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Feb 2018 · 12 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~May 2019 · 11 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jan 2021 · 19 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Jul 2022 · 15 months · monthly snapshot~Jul 2022 – ~Jun 2023 · 11 months · monthly snapshot~Jun 2023 – ~Dec 2023 · 6 months · monthly snapshot~Dec 2023 – ~Jun 2024 · 6 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Jun 2025 · 6 months · monthly snapshot~Jun 2025 – ~Aug 2025 · 2 months · monthly snapshot~Aug 2025 – ~Nov 2025 · 3 months · monthly snapshot~Nov 2025 – ~Feb 2026 · 3 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

19 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE4

  2. Nov 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE4

  3. Aug 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE4

  4. Jun 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE4

  5. Dec 2024 — Jun 2025 [monthly]

    Active Not Recruiting PHASE4

▶ Show 14 earlier versions

  1. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE4

  2. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE4

  3. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE4

  4. Dec 2023 — Jun 2024 [monthly]

    Active Not Recruiting PHASE4

  5. Jun 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE4

  6. Jul 2022 — Jun 2023 [monthly]

    Active Not Recruiting PHASE4

  7. Apr 2021 — Jul 2022 [monthly]

    Active Not Recruiting PHASE4

  8. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE4

  9. Jun 2019 — Jan 2021 [monthly]

    Active Not Recruiting PHASE4

  10. May 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE4

  11. Jun 2018 — May 2019 [monthly]

    Active Not Recruiting PHASE4

  12. Feb 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE4

    Status: Recruiting → Active Not Recruiting

  13. Feb 2017 — Feb 2018 [monthly]

    Recruiting PHASE4

  14. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE4

    First recorded

Dec 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • NAL PHARMA
  • Pfizer
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations