deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT02288247

A Study to Assess the Benefit of Treatment Beyond Progression With Enzalutamide in Men Who Are Starting Treatment With Docetaxel After Worsening of Their Prostate Cancer When Taking Enzalutamide Alone (PRESIDE)

A Randomized, Double Blind, Placebo-Controlled, Phase IIIb Study of the Efficacy and Safety of Continuing Enzalutamide in Chemotherapy Naïve Metastatic Castration Resistant Prostate Cancer Patients Treated With Docetaxel Plus Prednisolone Who Have Progressed on Enzalutamide Alone

Sponsor: Astellas Pharma Europe Ltd.

Conditions Metastatic Castration Resistant Prostate Cancer
Interventions Docetaxel Enzalutamide Placebo Prednisolone
Updated 48 times since 2017 Last updated: Apr 4, 2025 Started: Dec 1, 2014 Primary completion: Apr 30, 2020 Completion: Mar 15, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Metastatic Castration Resistant Prostate Cancer and is currently completed. Astellas Pharma Europe Ltd. leads this study, which shows 48 recorded versions since 2014 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Jun 2018 · 12 months · monthly snapshot~Jun 2018 – ~Jan 2019 · 7 months · monthly snapshot~Jan 2019 – ~Jul 2019 · 6 months · monthly snapshot~Jul 2019 – ~Nov 2019 · 4 months · monthly snapshot~Nov 2019 – ~Feb 2020 · 3 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Jan 2022 · 4 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Mar 2023 · 59 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Apr 2025 · 59 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

48 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. May 2025 — Sep 2025 [monthly]

    Completed PHASE3

  3. Apr 2025 — May 2025 [monthly]

    Completed PHASE3

  4. Feb 2025 — Apr 2025 [monthly]

    Completed PHASE3

  5. Sep 2024 — Feb 2025 [monthly]

    Completed PHASE3

▶ Show 43 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  2. May 2024 — Jul 2024 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  3. Mar 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE3

  4. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE3

  5. Dec 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  6. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  7. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  8. Aug 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  9. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  10. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  11. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  12. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  13. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  14. Jan 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  15. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE3

  16. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

  17. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  18. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  19. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

  20. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

  21. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE3

  22. Feb 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  23. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  24. Sep 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE3

  25. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  26. Apr 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

  27. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE3

  28. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  29. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE3

  30. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  31. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE3

  32. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

  33. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE3

  34. May 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  35. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  36. Feb 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  37. Nov 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  38. Jul 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE3

  39. Jan 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE3

  40. Jun 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE3

  41. Jun 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  42. Feb 2017 — Jun 2017 [monthly]

    Recruiting PHASE3

  43. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Dec 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Astellas Pharma Europe Ltd.
  • Medivation LLC, a wholly owned subsidiary of Pfizer Inc.
Data source: Astellas Pharma Inc

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aachen, Germany , Aberdeen, United Kingdom , Albi, France , Amsterdam, Netherlands , Ankara, Turkey (Türkiye) , Arezzo, Italy , Athens, Greece , Bergisch Gladbach, Germany , Blaricum, Netherlands , Bonheiden, Belgium and 69 more locations