deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT02372409

Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors

A Pilot Study of Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors

Sponsor: Washington University School of Medicine

Conditions Anaplastic Astrocytoma Astrocytoma Glioblastoma Glioma Mixed Glioma Mixed Oligoastrocytoma Oligodendroglioma Optic Glioma Pilocytic Astrocytoma
Interventions Doxorubicin Dynamic contrast-enhanced (DCE) MRI Dynamic susceptibility contrast (DSC) MRI Etoposide MRI-guided laser ablation
Updated 18 times since 2017 Last updated: Oct 21, 2024 Started: Aug 14, 2015 Primary completion: Mar 23, 2023 Completion: Mar 23, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Low accruals and competing clinical trials

Other terminated trials from Washington University School of Medicine

See all terminations from Washington University School of Medicine

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Browse all Anaplastic Astrocytoma trials

This PHASE2 trial investigates Anaplastic Astrocytoma and Astrocytoma and is currently terminated or withdrawn. Washington University School of Medicine leads this study, which shows 18 recorded versions since 2015 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Oct 2017 · 7 months · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Jun 2019 · 12 months · monthly snapshot~Jun 2019 – ~Feb 2020 · 8 months · monthly snapshot~Feb 2020 – ~Jul 2020 · 5 months · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~Apr 2022 · 12 months · monthly snapshot~Apr 2022 – ~Jul 2022 · 3 months · monthly snapshot~Jul 2022 – ~Feb 2023 · 7 months · monthly snapshot~Feb 2023 – ~Jul 2024 · 17 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Sep 2025 · 9 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

18 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE2

  2. Dec 2024 — Sep 2025 [monthly]

    Terminated PHASE2

  3. Sep 2024 — Dec 2024 [monthly]

    Terminated PHASE2

    Status: Recruiting → Terminated

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Feb 2023 — Jul 2024 [monthly]

    Recruiting PHASE2

▶ Show 13 earlier versions

  1. Jul 2022 — Feb 2023 [monthly]

    Recruiting PHASE2

  2. Apr 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  3. Apr 2021 — Apr 2022 [monthly]

    Recruiting PHASE2

  4. Feb 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  5. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  6. Jul 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    Phase: PHASE1 → PHASE2

  7. Feb 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  8. Jun 2019 — Feb 2020 [monthly]

    Recruiting PHASE1

  9. Jun 2018 — Jun 2019 [monthly]

    Recruiting PHASE1

  10. Oct 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

  11. Mar 2017 — Oct 2017 [monthly]

    Recruiting PHASE1

    Phase: EARLY_PHASE1 → PHASE1

  12. Feb 2017 — Mar 2017 [monthly]

    Recruiting EARLY_PHASE1

    Phase: Phase 0 → EARLY_PHASE1

  13. Jan 2017 — Feb 2017 [monthly]

    Recruiting Phase 0

    First recorded

Aug 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Washington University School of Medicine
Data source: Washington University School of Medicine

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations