deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 2-arm NCT02404441

Phase I/II Study of PDR001 in Patients With Advanced Malignancies

Open Label Multicenter Phase I/II Study of the Safety and Efficacy of PDR001 Administered to Patients With Advanced Malignancies

Sponsor: Novartis Pharmaceuticals

Conditions Anaplastic Thyroid Cancer Melanoma Non-small Sell Lung Cancer (NSCLC) Other Solid Tumors Triple Negative Breast Cancer
Interventions PDR001
Updated 29 times since 2017 Last updated: Aug 2, 2022 Started: Apr 27, 2015 Primary completion: Jul 21, 2020 Completion: Jul 21, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1/PHASE2 clinical study on Anaplastic Thyroid Cancer and Melanoma, this trial is completed. The trial is conducted by Novartis Pharmaceuticals and has accumulated 29 data snapshots since 2015. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~Jun 2017 · 2 months · monthly snapshot~Jun 2017 – ~Dec 2017 · 6 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Sep 2018 · 2 months · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Jul 2019 · 6 months · monthly snapshot~Jul 2019 – ~Jan 2020 · 6 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Oct 2021 · 6 months · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Sep 2022 · 9 months · monthly snapshot~Sep 2022 – ~Jul 2024 · 22 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 9 months · monthly snapshot

Change History

29 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE1/PHASE2

  3. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1/PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  5. Sep 2022 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

▶ Show 24 earlier versions

  1. Dec 2021 — Sep 2022 [monthly]

    Completed PHASE1_PHASE2

  2. Oct 2021 — Dec 2021 [monthly]

    Completed PHASE1_PHASE2

  3. Apr 2021 — Oct 2021 [monthly]

    Completed PHASE1_PHASE2

  4. Jan 2021 — Apr 2021 [monthly]

    Completed PHASE1_PHASE2

  5. Dec 2020 — Jan 2021 [monthly]

    Completed PHASE1_PHASE2

  6. Oct 2020 — Dec 2020 [monthly]

    Completed PHASE1_PHASE2

  7. Sep 2020 — Oct 2020 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

  8. Jul 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  9. May 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  10. Mar 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  11. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  12. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  13. Jul 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  14. Jan 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  15. Dec 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  16. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Active Not Recruiting → Recruiting

  17. Sep 2018 — Nov 2018 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  18. Jul 2018 — Sep 2018 [monthly]

    Recruiting PHASE1_PHASE2

  19. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1_PHASE2

  20. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  21. Jun 2017 — Dec 2017 [monthly]

    Recruiting PHASE1_PHASE2

  22. Apr 2017 — Jun 2017 [monthly]

    Recruiting PHASE1_PHASE2

  23. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE1_PHASE2

  24. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Apr 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novartis Pharmaceuticals
Data source: Novartis

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Adana, Turkey (Türkiye) , Amsterdam, Netherlands , Baltimore, United States , Bangkok, Thailand , Barcelona, Spain , Bologna, Italy , Boston, United States , Budapest, Hungary , Debrecen, Hungary , Edirne, Turkey (Türkiye) and 28 more locations