deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT02407678

REP1 Gene Replacement Therapy for Choroideremia (REGENERATE)

An Open Label Phase 2 Clinical Trial of Retinal Gene Therapy for Choroideremia Using an Adeno-associated Viral Vector (AAV2) Encoding Rab-escort Protein 1 (REP1)

Sponsor: Moorfields Eye Hospital NHS Foundation Trust

Conditions Choroideremia
Interventions AAV-mediated REP1 gene replacement
Updated 8 times since 2017 Last updated: Aug 4, 2021 Started: Aug 16, 2016 Primary completion: Jul 23, 2021 Completion: Jul 23, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Choroideremia, this trial is completed. The trial is conducted by Moorfields Eye Hospital NHS Foundation Trust and has accumulated 8 data snapshots since 2016. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Dec 2017 · 11 months · monthly snapshotRecruiting~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshotRecruiting~Jun 2018 – ~Aug 2019 · 14 months · monthly snapshotRecruiting~Aug 2019 – ~Jan 2021 · 17 months · monthly snapshotActive Not Recruiting~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshotActive Not Recruiting~Sep 2021 – ~Jul 2024 · 34 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – present · 22 months · monthly snapshotCompleted

Change History

8 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  3. Sep 2021 — Jul 2024 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  4. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  5. Aug 2019 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

▶ Show 3 earlier versions

  1. Jun 2018 — Aug 2019 [monthly]

    Recruiting PHASE2

  2. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  3. Jan 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

    First recorded

Aug 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Moorfields Eye Hospital NHS Foundation Trust
  • University College, London
  • University of Oxford
Data source: University of Oxford

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations