deltatrials
Recruiting PHASE1 INTERVENTIONAL 4-arm NCT02429557

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Conditions Autonomic Failure Multiple System Atrophy Orthostatic Hypotension Pure Autonomic Failure
Interventions Abdominal compression Placebo pill Sham abdominal compression midodrine
Updated 20 times since 2017 Last updated: Jan 8, 2026 Started: Apr 30, 2015 Primary completion: Nov 15, 2026 Completion: Dec 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Autonomic Failure and Multiple System Atrophy, this trial is actively recruiting participants. The trial is conducted by National Heart, Lung, and Blood Institute (NHLBI) and has accumulated 20 data snapshots since 2015. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Mar 2019 · 9 months · monthly snapshot~Mar 2019 – ~Mar 2020 · 12 months · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Oct 2020 · 5 months · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Dec 2021 · 9 months · monthly snapshot~Dec 2021 – ~Sep 2022 · 9 months · monthly snapshot~Sep 2022 – ~Apr 2023 · 7 months · monthly snapshot~Apr 2023 – ~Apr 2024 · 12 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Jun 2025 · 8 months · monthly snapshot~Jun 2025 – ~Feb 2026 · 8 months · monthly snapshot~Feb 2026 – present · 7 months · monthly snapshot

Change History

20 versions recorded

  1. Feb 2026 — Present [monthly]

    Recruiting PHASE1

  2. Jun 2025 — Feb 2026 [monthly]

    Recruiting PHASE1

  3. Oct 2024 — Jun 2025 [monthly]

    Recruiting PHASE1

  4. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE1

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

▶ Show 15 earlier versions

  1. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  2. Apr 2023 — Apr 2024 [monthly]

    Recruiting PHASE1

  3. Sep 2022 — Apr 2023 [monthly]

    Recruiting PHASE1

  4. Dec 2021 — Sep 2022 [monthly]

    Recruiting PHASE1

  5. Mar 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  6. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  7. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  8. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  9. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  10. May 2020 — Oct 2020 [monthly]

    Suspended PHASE1

    Status: Enrolling By Invitation → Suspended

  11. Mar 2020 — May 2020 [monthly]

    Enrolling By Invitation PHASE1

    Status: Recruiting → Enrolling By Invitation

  12. Mar 2019 — Mar 2020 [monthly]

    Recruiting PHASE1

  13. Jun 2018 — Mar 2019 [monthly]

    Recruiting PHASE1

  14. Feb 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

    Phase: NA → PHASE1

  15. Jan 2017 — Feb 2017 [monthly]

    Recruiting NA

    First recorded

Apr 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Vanderbilt University Medical Center
Data source: Vanderbilt University Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations