deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT02437110

HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Conditions Amyotrophic Lateral Sclerosis
Interventions Darunavir Dolutegravir Ritonavir Tenofovir alafenamide (TAF)
Updated 37 times since 2017 Last updated: Dec 19, 2023 Started: Apr 1, 2019 Primary completion: Nov 17, 2022 Completion: May 9, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Amyotrophic Lateral Sclerosis and is currently completed. National Institute of Neurological Disorders and Stroke (NINDS) leads this study, which shows 37 recorded versions since 2019 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Jun 2018 · 17 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Sep 2019 · 3 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Jun 2020 · 4 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Feb 2022 · 2 months · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Feb 2024 · 12 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 21 months · monthly snapshot

Change History

37 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Feb 2024 — Jul 2024 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  4. Feb 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

▶ Show 32 earlier versions

  1. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE1

  2. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  3. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

  4. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  5. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  6. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  7. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  8. Feb 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  9. Dec 2021 — Feb 2022 [monthly]

    Recruiting PHASE1

  10. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  11. Sep 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  12. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  13. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  14. Sep 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  15. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  16. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  17. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  18. Feb 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  19. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  20. Nov 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  21. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  22. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  23. Jun 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

    Status: Enrolling By Invitation → Recruiting

  24. May 2019 — Jun 2019 [monthly]

    Enrolling By Invitation PHASE1

  25. Apr 2019 — May 2019 [monthly]

    Enrolling By Invitation PHASE1

  26. Feb 2019 — Apr 2019 [monthly]

    Enrolling By Invitation PHASE1

  27. Jan 2019 — Feb 2019 [monthly]

    Enrolling By Invitation PHASE1

  28. Dec 2018 — Jan 2019 [monthly]

    Enrolling By Invitation PHASE1

  29. Oct 2018 — Dec 2018 [monthly]

    Enrolling By Invitation PHASE1

  30. Sep 2018 — Oct 2018 [monthly]

    Enrolling By Invitation PHASE1

  31. Jun 2018 — Sep 2018 [monthly]

    Enrolling By Invitation PHASE1

  32. Jan 2017 — Jun 2018 [monthly]

    Enrolling By Invitation PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute of Neurological Disorders and Stroke (NINDS)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations