deltatrials
Active Not Recruiting PHASE1/PHASE2 INTERVENTIONAL 7-arm NCT02444741

Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer

Phase I/II Trial of MK-3475 and Hypofractionated Stereotactic Radiation Therapy in Patients With NSCLC

Sponsor: M.D. Anderson Cancer Center

Conditions Malignant Solid Neoplasm Metastatic Lung Non-Small Cell Carcinoma Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions 3-Dimensional Conformal Radiation Therapy Intensity-Modulated Radiation Therapy Laboratory Biomarker Analysis Pembrolizumab Proton Beam Radiation Therapy Radiation Therapy Stereotactic Body Radiation Therapy
Updated 22 times since 2017 Last updated: Oct 7, 2025 Started: Sep 17, 2015 Primary completion: Sep 30, 2026 Completion: Sep 30, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02444741, this PHASE1/PHASE2 trial focuses on Malignant Solid Neoplasm and Metastatic Lung Non-Small Cell Carcinoma and remains ongoing. Sponsored by M.D. Anderson Cancer Center, it has been updated 22 times since 2015, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Jan 2018 · 10 months · monthly snapshot~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Feb 2019 · 8 months · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Jul 2020 · 12 months · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Feb 2022 · 10 months · monthly snapshot~Feb 2022 – ~Sep 2022 · 7 months · monthly snapshot~Sep 2022 – ~Mar 2023 · 6 months · monthly snapshot~Mar 2023 – ~Sep 2023 · 6 months · monthly snapshot~Sep 2023 – ~Mar 2024 · 6 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Oct 2025 · 7 months · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – present · 8 months · monthly snapshot

Change History

22 versions recorded

  1. Nov 2025 — Present [monthly]

    Active Not Recruiting PHASE1/PHASE2

  2. Oct 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  3. Mar 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  4. Sep 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

▶ Show 17 earlier versions

  1. Mar 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  2. Sep 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  3. Mar 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  4. Sep 2022 — Mar 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  5. Feb 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  6. Apr 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  7. Jan 2021 — Apr 2021 [monthly]

    Recruiting PHASE1_PHASE2

  8. Jul 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  9. Jul 2019 — Jul 2020 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Active Not Recruiting → Recruiting

  10. Jun 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  11. Apr 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  12. Feb 2019 — Apr 2019 [monthly]

    Recruiting PHASE1_PHASE2

  13. Jun 2018 — Feb 2019 [monthly]

    Recruiting PHASE1_PHASE2

  14. Jan 2018 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  15. Mar 2017 — Jan 2018 [monthly]

    Recruiting PHASE1_PHASE2

  16. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE1_PHASE2

  17. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Sep 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations