deltatrials
Recruiting PHASE3 INTERVENTIONAL 1-arm NCT02445222

CAR-T Long Term Follow Up (LTFU) Study (PAVO)

Long Term Follow-Up of Patients Exposed to Lentiviral-Based CAR T-Cell Therapy

Sponsor: Novartis Pharmaceuticals

Conditions Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program
Interventions Previously treated CAR-T patients
Updated 47 times since 2017 Last updated: Oct 26, 2025 Started: Nov 2, 2015 Primary completion: Feb 22, 2036 Completion: Feb 22, 2036
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program and is currently actively recruiting participants. Novartis Pharmaceuticals leads this study, which shows 47 recorded versions since 2015 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jan 2018 · 11 months · monthly snapshot~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Oct 2018 · 4 months · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Aug 2020 · 3 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~Jul 2022 · 3 months · monthly snapshot~Jul 2022 – ~Dec 2022 · 5 months · monthly snapshot~Dec 2022 – ~May 2023 · 5 months · monthly snapshot~May 2023 – ~Nov 2023 · 6 months · monthly snapshot~Nov 2023 – ~Apr 2024 · 5 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Apr 2025 · 4 months · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Aug 2025 · 2 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – present · 10 months · monthly snapshot

Change History

47 versions recorded

  1. Nov 2025 — Present [monthly]

    Recruiting PHASE3

  2. Sep 2025 — Nov 2025 [monthly]

    Recruiting PHASE3

  3. Aug 2025 — Sep 2025 [monthly]

    Recruiting PHASE3

  4. Jun 2025 — Aug 2025 [monthly]

    Recruiting PHASE3

  5. May 2025 — Jun 2025 [monthly]

    Recruiting PHASE3

▶ Show 42 earlier versions

  1. Apr 2025 — May 2025 [monthly]

    Recruiting PHASE3

  2. Dec 2024 — Apr 2025 [monthly]

    Recruiting PHASE3

  3. Nov 2024 — Dec 2024 [monthly]

    Recruiting PHASE3

  4. Sep 2024 — Nov 2024 [monthly]

    Recruiting PHASE3

  5. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  6. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE3

  7. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE3

    Phase: NA → PHASE3

  8. Nov 2023 — Apr 2024 [monthly]

    Recruiting NA

  9. May 2023 — Nov 2023 [monthly]

    Recruiting NA

  10. Dec 2022 — May 2023 [monthly]

    Recruiting NA

  11. Jul 2022 — Dec 2022 [monthly]

    Recruiting NA

  12. Apr 2022 — Jul 2022 [monthly]

    Recruiting NA

  13. Mar 2022 — Apr 2022 [monthly]

    Recruiting NA

  14. Feb 2022 — Mar 2022 [monthly]

    Recruiting NA

  15. Jan 2022 — Feb 2022 [monthly]

    Recruiting NA

  16. Nov 2021 — Jan 2022 [monthly]

    Recruiting NA

  17. Sep 2021 — Nov 2021 [monthly]

    Recruiting NA

  18. Jun 2021 — Sep 2021 [monthly]

    Recruiting NA

  19. May 2021 — Jun 2021 [monthly]

    Recruiting NA

  20. Apr 2021 — May 2021 [monthly]

    Recruiting NA

  21. Mar 2021 — Apr 2021 [monthly]

    Recruiting NA

  22. Jan 2021 — Mar 2021 [monthly]

    Recruiting NA

  23. Oct 2020 — Jan 2021 [monthly]

    Recruiting NA

  24. Aug 2020 — Oct 2020 [monthly]

    Recruiting NA

  25. May 2020 — Aug 2020 [monthly]

    Recruiting NA

  26. Mar 2020 — May 2020 [monthly]

    Recruiting NA

  27. Jan 2020 — Mar 2020 [monthly]

    Recruiting NA

  28. Dec 2019 — Jan 2020 [monthly]

    Recruiting NA

  29. Nov 2019 — Dec 2019 [monthly]

    Recruiting NA

  30. Oct 2019 — Nov 2019 [monthly]

    Recruiting NA

  31. Jul 2019 — Oct 2019 [monthly]

    Recruiting NA

  32. Jun 2019 — Jul 2019 [monthly]

    Recruiting NA

  33. May 2019 — Jun 2019 [monthly]

    Recruiting NA

  34. Apr 2019 — May 2019 [monthly]

    Recruiting NA

  35. Feb 2019 — Apr 2019 [monthly]

    Recruiting NA

  36. Dec 2018 — Feb 2019 [monthly]

    Recruiting NA

  37. Nov 2018 — Dec 2018 [monthly]

    Recruiting NA

  38. Oct 2018 — Nov 2018 [monthly]

    Recruiting NA

  39. Jun 2018 — Oct 2018 [monthly]

    Recruiting NA

  40. Jan 2018 — Jun 2018 [monthly]

    Recruiting NA

  41. Feb 2017 — Jan 2018 [monthly]

    Recruiting NA

  42. Jan 2017 — Feb 2017 [monthly]

    Recruiting NA

    First recorded

Nov 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novartis Pharmaceuticals
  • University of Pennsylvania
Data source: Novartis

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Amsterdam, Netherlands , Ann Arbor, United States , Atlanta, United States , Barcelona, Spain , Beijing, China , Berlin, Germany , Birmingham, United Kingdom , Bologna, Italy , Boston, United States , Camperdown, Australia and 73 more locations