Unknown PHASE2/PHASE3 INTERVENTIONAL 2-arm NCT02448849

Autologous BM-MSC Transplantation in Combination With Platelet Lysate (PL) for Nonunion Treatment

Use of Autologous Bone Marrow Derived Mesenchymal Stromal Cells in Combination With Platelet Lysate Product for Human Long Bone Nonunion Treatment, A Phase 2-3 Clinical Trial

Sponsor: Royan Institute

Conditions Bone Fracture

Interventions Percutaneous injection

Updated 7 times since 2017 Last updated: Oct 29, 2015 Started: Jun 30, 2015 Primary completion: Apr 30, 2017 Completion: Aug 31, 2017

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2/PHASE3 trial investigates Bone Fracture and is currently ongoing. Royan Institute leads this study, which shows 7 recorded versions since 2015 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Unknown PHASE2/PHASE3
Sep 2024 — Sep 2025 [monthly]

Unknown PHASE2/PHASE3
Jul 2024 — Sep 2024 [monthly]

Unknown PHASE2/PHASE3

Status: Unknown Status → Unknown · Phase: PHASE2_PHASE3 → PHASE2/PHASE3
Jan 2021 — Jul 2024 [monthly]

Unknown Status PHASE2_PHASE3
Jun 2018 — Jan 2021 [monthly]

Unknown Status PHASE2_PHASE3

▶ Show 2 earlier versions

Oct 2017 — Jun 2018 [monthly]

Unknown Status PHASE2_PHASE3

Status: Recruiting → Unknown Status
Jan 2017 — Oct 2017 [monthly]

Recruiting PHASE2_PHASE3

First recorded

Jun 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Royan Institute

Data source: Royan Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Tehran, Iran