deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT02452528

Study of ARC-520 in Participants With Hepatitis B Virus e Antigen (HBeAg) Positive Chronic Hepatitis B Virus

A Multicenter, Randomized, Double-blind, Placebo-controlled, Multi-dose Study to Determine the Depth of Hepatitis B Surface Antigen (HBsAg) Reduction Following Intravenous ARC-520 in Combination With Entecavir or Tenofovir in Patients With HBeAg Positive, Chronic Hepatitis B Virus (HBV) Infection

Sponsor: Arrowhead Pharmaceuticals

Updated 10 times since 2017 Last updated: Oct 7, 2025 Started: Aug 31, 2015 Primary completion: Dec 31, 2016 Completion: Dec 31, 2016
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Company decision to discontinue trial

A PHASE2 clinical study on Chronic Hepatitis B, this trial is terminated or withdrawn. The trial is conducted by Arrowhead Pharmaceuticals and has accumulated 10 data snapshots since 2015. Infectious disease trials contribute critical data for public health response and treatment development.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotTerminated~Feb 2017 – ~Nov 2017 · 9 months · monthly snapshotTerminated~Nov 2017 – ~Jun 2018 · 7 months · monthly snapshotTerminated~Jun 2018 – ~Jan 2021 · 31 months · monthly snapshotTerminated~Jan 2021 – ~Dec 2022 · 23 months · monthly snapshotTerminated~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshotTerminated~Jan 2023 – ~Jul 2024 · 18 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – ~Dec 2025 · 15 months · monthly snapshotTerminated~Dec 2025 – present · 9 months · monthly snapshotTerminated

Change History

10 versions recorded
  1. Dec 2025 — Present [monthly]

    Terminated PHASE2

  2. Sep 2024 — Dec 2025 [monthly]

    Terminated PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  4. Jan 2023 — Jul 2024 [monthly]

    Terminated PHASE2

  5. Dec 2022 — Jan 2023 [monthly]

    Terminated PHASE2

Show 5 earlier versions
  1. Jan 2021 — Dec 2022 [monthly]

    Terminated PHASE2

  2. Jun 2018 — Jan 2021 [monthly]

    Terminated PHASE2

  3. Nov 2017 — Jun 2018 [monthly]

    Terminated PHASE2

  4. Feb 2017 — Nov 2017 [monthly]

    Terminated PHASE2

  5. Jan 2017 — Feb 2017 [monthly]

    Terminated PHASE2

    First recorded

Aug 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Arrowhead Pharmaceuticals
Data source: Arrowhead Pharmaceuticals

For direct contact, visit the study record on ClinicalTrials.gov .