deltatrials
Completed PHASE2 INTERVENTIONAL 3-arm NCT02465268

Vaccine Therapy for the Treatment of Newly Diagnosed Glioblastoma Multiforme (ATTAC-II)

ATTAC-II: A Phase II Randomized, Blinded, and Placebo-controlled Trial of CMV RNA-Pulsed Dendritic Cells With Tetanus-Diphtheria Toxoid Vaccine in Patients With Newly-Diagnosed Glioblastoma

Sponsor: National Cancer Institute (NCI)

Conditions Astrocytoma, Grade IV GBM Glioblastoma Glioblastoma Multiforme Malignant Glioma
Interventions Saline Td pp65-flLAMP DC with GM-CSF pp65-shLAMP DC with GM-CSF unpulsed PBMC and saline
Updated 33 times since 2017 Last updated: Dec 19, 2024 Started: Aug 9, 2016 Primary completion: Nov 30, 2023 Completion: Nov 30, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Astrocytoma, Grade IV and GBM and is currently completed. National Cancer Institute (NCI) leads this study, which shows 33 recorded versions since 2016 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Sep 2017 · 3 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Mar 2018 · 5 months · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Sep 2019 · 4 months · monthly snapshot~Sep 2019 – ~Dec 2019 · 3 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Dec 2020 · 11 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2022 · 13 months · monthly snapshot~Feb 2022 – ~Dec 2022 · 10 months · monthly snapshot~Dec 2022 – ~May 2023 · 5 months · monthly snapshot~May 2023 – ~Oct 2023 · 5 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Jan 2024 · 2 months · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Feb 2025 · 3 months · monthly snapshot~Feb 2025 – present · 16 months · monthly snapshot

Change History

33 versions recorded

  1. Feb 2025 — Present [monthly]

    Completed PHASE2

  2. Nov 2024 — Feb 2025 [monthly]

    Completed PHASE2

  3. Sep 2024 — Nov 2024 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  5. Apr 2024 — Jul 2024 [monthly]

    Completed PHASE2

▶ Show 28 earlier versions

  1. Feb 2024 — Apr 2024 [monthly]

    Completed PHASE2

  2. Jan 2024 — Feb 2024 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  3. Nov 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  5. May 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  6. Dec 2022 — May 2023 [monthly]

    Recruiting PHASE2

  7. Feb 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  8. Jan 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

  9. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  10. Jan 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  11. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  12. Sep 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  13. May 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  14. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  15. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  16. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  17. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  18. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  19. Oct 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  20. Aug 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  21. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  22. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  23. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE2

  24. Oct 2017 — Mar 2018 [monthly]

    Recruiting PHASE2

  25. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  26. Jun 2017 — Sep 2017 [monthly]

    Recruiting PHASE2

  27. Feb 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  28. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Aug 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
  • University of Florida
Data source: University of Florida

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations