deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT02478398

Efficacy and Safety Study of RAGWITEK™ (MK-3641) in Children With Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (MK-3641-008)

A Phase III, Randomized, Placebo-Controlled Clinical Trial to Study the Efficacy and Safety of MK-3641, a Ragweed (Ambrosia Artemisiifolia) Sublingual Immunotherapy Tablet, in Children With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma

Sponsor: Merck Sharp & Dohme LLC

Conditions Rhinitis, Allergic, Seasonal
Interventions Albuterol/Salbutamol Loratadine Mometasone furoate monohydrate Olopatadine Placebo Self-injectable epinephrine Short ragweed pollen allergen extract
Updated 26 times since 2017 Last updated: Aug 21, 2019 Started: Jul 20, 2015 Primary completion: Nov 9, 2018 Completion: Nov 19, 2018
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02478398, this PHASE3 trial focuses on Rhinitis, Allergic, Seasonal and remains completed. Sponsored by Merck Sharp & Dohme LLC, it has been updated 26 times since 2015, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Sep 2017 · 3 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~May 2018 · 30 days · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Dec 2018 · 4 months · monthly snapshot~Dec 2018 – ~Aug 2019 · 8 months · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Jan 2021 · 15 months · monthly snapshot~Jan 2021 – ~Jun 2022 · 17 months · monthly snapshot~Jun 2022 – ~Jul 2024 · 25 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 19 months · monthly snapshot~Jan 2026 – present · 3 months · monthly snapshot

Change History

26 versions recorded

  1. Jan 2026 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Present [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Jun 2022 — Jul 2024 [monthly]

    Completed PHASE3

  5. Jan 2021 — Jun 2022 [monthly]

    Completed PHASE3

▶ Show 21 earlier versions

  1. Oct 2019 — Jan 2021 [monthly]

    Completed PHASE3

  2. Aug 2019 — Oct 2019 [monthly]

    Completed PHASE3

  3. Dec 2018 — Aug 2019 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  4. Aug 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE3

  5. Jul 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  6. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  7. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  8. Apr 2018 — May 2018 [monthly]

    Recruiting PHASE3

  9. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE3

  10. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE3

  11. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE3

  12. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE3

  13. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

  14. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE3

  15. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  16. Jun 2017 — Sep 2017 [monthly]

    Recruiting PHASE3

  17. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE3

  18. Apr 2017 — May 2017 [monthly]

    Recruiting PHASE3

  19. Mar 2017 — Apr 2017 [monthly]

    Recruiting PHASE3

  20. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE3

  21. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Jul 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Merck Sharp & Dohme LLC
Data source: Merck Sharp & Dohme LLC

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

No location information available.