deltatrials
Terminated PHASE1 INTERVENTIONAL 4-arm NCT02479204

Clinical Study to Investigate Safety and Effects on Heart Rate, Blood Pressure, and Pharmacokinetic Interactions of ACT-334441

Single-center, Open-label, Randomized, Multiple-dose, Parallel-group Study to Investigate Safety and Effects on Heart Rate, Blood Pressure, and Pharmacokinetic Interactions of ACT-334441 Combined With Calcium-channel Blocker (Diltiazem) or Beta-blocker (Atenolol) Treatment in Healthy Subjects

Sponsor: Viatris Innovation GmbH

Updated 11 times since 2017 Last updated: Sep 16, 2025 Started: Apr 28, 2015 Primary completion: May 1, 2016 Completion: May 1, 2016
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Based on results from the pilot phase, the study is terminated. No safety events leading to discontinuation were reported

A PHASE1 clinical study on Healthy Subjects, this trial is terminated or withdrawn. The trial is conducted by Viatris Innovation GmbH and has accumulated 11 data snapshots since 2015. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Aug 2017 · 7 months · monthly snapshotTerminated~Aug 2017 – ~May 2018 · 9 months · monthly snapshotTerminated~May 2018 – ~Jun 2018 · 31 days · monthly snapshotTerminated~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshotTerminated~Aug 2018 – ~Nov 2020 · 27 months · monthly snapshotTerminated~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshotTerminated~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshotTerminated~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – ~Oct 2025 · 13 months · monthly snapshotTerminated~Oct 2025 – present · 11 months · monthly snapshotTerminated

Change History

11 versions recorded
  1. Oct 2025 — Present [monthly]

    Terminated PHASE1

  2. Sep 2024 — Oct 2025 [monthly]

    Terminated PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  4. Dec 2021 — Jul 2024 [monthly]

    Terminated PHASE1

  5. Jan 2021 — Dec 2021 [monthly]

    Terminated PHASE1

Show 6 earlier versions
  1. Nov 2020 — Jan 2021 [monthly]

    Terminated PHASE1

  2. Aug 2018 — Nov 2020 [monthly]

    Terminated PHASE1

  3. Jun 2018 — Aug 2018 [monthly]

    Terminated PHASE1

  4. May 2018 — Jun 2018 [monthly]

    Terminated PHASE1

  5. Aug 2017 — May 2018 [monthly]

    Terminated PHASE1

  6. Jan 2017 — Aug 2017 [monthly]

    Terminated PHASE1

    First recorded

Apr 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Viatris Innovation GmbH
Data source: Viatris Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations