deltatrials
Recruiting PHASE2 INTERVENTIONAL 1-arm NCT02479698

Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus

Phase II Study Assessing the Effect of BK Specific CTL Lines Generated by Ex Vivo Expansion in Patients With BK Virus Infection and JC Virus Infection

Sponsor: M.D. Anderson Cancer Center

Conditions Acquired Immunodeficiency Syndrome BK Virus Infection Human Immunodeficiency Virus JC Virus Infection Malignant Neoplasm Merkel Cell Carcinoma Merkel Cell Polyomavirus Infection Viral Encephalitis
Interventions Allogeneic BK-specific Cytotoxic T-lymphocytes Laboratory Biomarker Analysis
Updated 27 times since 2017 Last updated: Nov 14, 2025 Started: Jul 23, 2015 Primary completion: Jul 31, 2027 Completion: Jul 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Acquired Immunodeficiency Syndrome and BK Virus Infection and is currently actively recruiting participants. M.D. Anderson Cancer Center leads this study, which shows 27 recorded versions since 2015 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Oct 2017 · 8 months · monthly snapshot~Oct 2017 – ~Mar 2018 · 5 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Mar 2019 · 9 months · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Sep 2020 · 9 months · monthly snapshot~Sep 2020 – ~Dec 2020 · 3 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Nov 2022 · 11 months · monthly snapshot~Nov 2022 – ~Jul 2023 · 8 months · monthly snapshot~Jul 2023 – ~Nov 2023 · 4 months · monthly snapshot~Nov 2023 – ~Jan 2024 · 2 months · monthly snapshot~Jan 2024 – ~Jul 2024 · 6 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Aug 2025 · 5 months · monthly snapshot~Aug 2025 – ~Dec 2025 · 4 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

27 versions recorded

  1. Dec 2025 — Present [monthly]

    Recruiting PHASE2

  2. Aug 2025 — Dec 2025 [monthly]

    Recruiting PHASE2

  3. Mar 2025 — Aug 2025 [monthly]

    Recruiting PHASE2

  4. Sep 2024 — Mar 2025 [monthly]

    Recruiting PHASE2

  5. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

▶ Show 22 earlier versions

  1. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2

  2. Jan 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  3. Nov 2023 — Jan 2024 [monthly]

    Recruiting PHASE2

  4. Jul 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  5. Nov 2022 — Jul 2023 [monthly]

    Recruiting PHASE2

  6. Dec 2021 — Nov 2022 [monthly]

    Recruiting PHASE2

  7. Sep 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  8. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  9. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  10. Sep 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  11. Dec 2019 — Sep 2020 [monthly]

    Recruiting PHASE2

  12. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  13. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  14. Jul 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  15. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  16. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  17. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  18. Jun 2018 — Mar 2019 [monthly]

    Recruiting PHASE2

  19. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  20. Oct 2017 — Mar 2018 [monthly]

    Recruiting PHASE2

  21. Feb 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  22. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Jul 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations