deltatrials
Completed PHASE1 INTERVENTIONAL 2-arm NCT02491281

First-in-human Single Ascending Dose Study of LNA043 in Patients Scheduled for Total Knee Replacement

A Randomized, Placebo Controlled, Double-blind First-in-human Single Ascending Dose Study of LNA043 in Primary Osteoarthritis Patients Scheduled for Total Knee Replacement

Sponsor: Novartis Pharmaceuticals

Interventions LNA043 Placebo
Updated 11 times since 2017 Last updated: Dec 9, 2020 Started: Nov 16, 2015 Primary completion: Feb 7, 2018 Completion: Mar 6, 2018
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery and is currently completed. Novartis Pharmaceuticals leads this study, which shows 11 recorded versions since 2015 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotRecruiting~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshotRecruiting~Apr 2017 – ~Jun 2017 · 2 months · monthly snapshotRecruiting~Jun 2017 – ~Oct 2017 · 4 months · monthly snapshotRecruiting~Oct 2017 – ~May 2018 · 7 months · monthly snapshotRecruiting~May 2018 – ~Jun 2018 · 31 days · monthly snapshotCompleted~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshotCompleted~Sep 2018 – ~Jan 2021 · 28 months · monthly snapshotCompleted~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – present · 24 months · monthly snapshotCompleted

Change History

11 versions recorded
  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE1

  4. Sep 2018 — Jan 2021 [monthly]

    Completed PHASE1

  5. Jun 2018 — Sep 2018 [monthly]

    Completed PHASE1

Show 6 earlier versions
  1. May 2018 — Jun 2018 [monthly]

    Completed PHASE1

    Status: RecruitingCompleted

  2. Oct 2017 — May 2018 [monthly]

    Recruiting PHASE1

  3. Jun 2017 — Oct 2017 [monthly]

    Recruiting PHASE1

  4. Apr 2017 — Jun 2017 [monthly]

    Recruiting PHASE1

  5. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE1

  6. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Nov 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novartis Pharmaceuticals
Data source: Novartis

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations