deltatrials
Completed PHASE3 INTERVENTIONAL 3-arm NCT02500381

Study of SRP-4045 (Casimersen) and SRP-4053 (Golodirsen) in Participants With Duchenne Muscular Dystrophy (DMD) (ESSENCE)

A Double-Blind, Placebo-Controlled, Multi-Center Study With an Open-Label Extension to Evaluate the Efficacy and Safety of SRP-4045 and SRP-4053 in Patients With Duchenne Muscular Dystrophy

Sponsor: Sarepta Therapeutics, Inc.

Conditions Duchenne Muscular Dystrophy
Interventions Placebo SRP-4045 SRP-4053
Updated 47 times since 2017 Last updated: Nov 14, 2025 Started: Sep 28, 2016 Primary completion: Nov 12, 2024 Completion: Oct 16, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Duchenne Muscular Dystrophy, this trial is completed. The trial is conducted by Sarepta Therapeutics, Inc. and has accumulated 47 data snapshots since 2016. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Feb 2018 · 3 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Jan 2020 · 5 months · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Apr 2022 · 7 months · monthly snapshot~Apr 2022 – ~Jul 2022 · 3 months · monthly snapshot~Jul 2022 – ~Dec 2022 · 5 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2024 · 13 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Jan 2025 · 3 months · monthly snapshot~Jan 2025 – ~Sep 2025 · 8 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

47 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  2. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Jan 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Oct 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

▶ Show 42 earlier versions

  1. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  2. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  3. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  4. Mar 2023 — Apr 2024 [monthly]

    Active Not Recruiting PHASE3

  5. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  6. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE3

  7. Jul 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  8. Apr 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  9. Sep 2021 — Apr 2022 [monthly]

    Recruiting PHASE3

  10. Apr 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  11. Jan 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  12. Aug 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  13. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  14. May 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  15. Mar 2020 — May 2020 [monthly]

    Recruiting PHASE3

  16. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  17. Aug 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

  18. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  19. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  20. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  21. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  22. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  23. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

  24. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

    Status: Active Not Recruiting → Recruiting

  25. Nov 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  26. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  27. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  28. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  29. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  30. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE3

  31. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE3

  32. Nov 2017 — Feb 2018 [monthly]

    Recruiting PHASE3

  33. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE3

  34. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  35. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE3

  36. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE3

  37. Jun 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

  38. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE3

  39. Apr 2017 — May 2017 [monthly]

    Recruiting PHASE3

  40. Mar 2017 — Apr 2017 [monthly]

    Recruiting PHASE3

  41. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE3

  42. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Sep 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Sarepta Therapeutics, Inc.
Data source: Sarepta Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Ahmedabad, India , Atlanta, United States , Barcelona, Spain , Belgrade, Serbia , Berlin, Germany , Boston, United States , Brno, Czechia , Budapest, Hungary , Buenos Aires, Argentina , Calgary, Canada and 64 more locations