deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 2-arm NCT02500849

Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients

A Pilot Study to Evaluate the Feasibility, Safety and Engraftment of Zinc Finger Nuclease (ZFN) CCR5 Modified CD34+ Hematopoietic Stem/Progenitor Cells (SB-728mR-HSPC) in HIV-1 (R5) Infected Patients

Sponsor: California Institute for Regenerative Medicine (CIRM)

Conditions HIV
Interventions SB-728mR-HSPC Infusion 3 days following busulfan conditioning
Updated 18 times since 2017 Last updated: Oct 8, 2025 Started: Mar 10, 2016 Primary completion: Aug 24, 2026 Completion: Aug 24, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on HIV, this trial is ongoing. The trial is conducted by California Institute for Regenerative Medicine (CIRM) and has accumulated 18 data snapshots since 2016. Infectious disease trials contribute critical data for public health response and treatment development.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Sep 2018 · 2 months · monthly snapshot~Sep 2018 – ~Feb 2019 · 5 months · monthly snapshot~Feb 2019 – ~Jun 2019 · 4 months · monthly snapshot~Jun 2019 – ~Jan 2021 · 19 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Apr 2022 · 7 months · monthly snapshot~Apr 2022 – ~Apr 2023 · 12 months · monthly snapshot~Apr 2023 – ~Feb 2024 · 10 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Feb 2025 · 4 months · monthly snapshot~Feb 2025 – ~Aug 2025 · 6 months · monthly snapshot~Aug 2025 – ~Nov 2025 · 3 months · monthly snapshot~Nov 2025 – present · 8 months · monthly snapshot

Change History

18 versions recorded

  1. Nov 2025 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Aug 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Feb 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Oct 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 13 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Feb 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Apr 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Apr 2022 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  6. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  7. Jun 2019 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  8. Feb 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  9. Sep 2018 — Feb 2019 [monthly]

    Recruiting PHASE1

  10. Jul 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  11. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

  12. Feb 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

  13. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Mar 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • California Institute for Regenerative Medicine (CIRM)
  • City of Hope Medical Center
  • Sangamo Therapeutics
Data source: City of Hope Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations