deltatrials
Completed PHASE3 INTERVENTIONAL 4-arm NCT02504268

Effects of Abatacept in Patients With Early Rheumatoid Arthritis (AVERT-2)

A Phase 3B, Randomized, Double-Blind Clinical Trial to Evaluate the Efficacy and Safety of Abatacept SC in Combination With Methotrexate Compared to Methotrexate Monotherapy in Achieving Clinical Remission in Adults With Early Rheumatoid Arthritis Who Are Methotrexate Naive

Sponsor: Bristol-Myers Squibb

Conditions Rheumatoid Arthritis
Interventions Abatacept Abatacept Placebo Methotrexate Methotrexate Placebo
Updated 25 times since 2017 Last updated: Jun 25, 2021 Started: Sep 3, 2015 Primary completion: Jan 16, 2017 Completion: Mar 19, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Rheumatoid Arthritis and is currently completed. Bristol-Myers Squibb leads this study, which shows 25 recorded versions since 2015 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~Dec 2017 · 8 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~May 2019 · 11 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Jul 2024 · 34 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – present · 8 months · monthly snapshot

Change History

25 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE3

  2. Nov 2025 — Dec 2025 [monthly]

    Completed PHASE3

  3. Sep 2025 — Nov 2025 [monthly]

    Completed PHASE3

  4. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  5. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

▶ Show 20 earlier versions

  1. Sep 2021 — Jul 2024 [monthly]

    Completed PHASE3

  2. Jan 2021 — Sep 2021 [monthly]

    Completed PHASE3

  3. Jul 2020 — Jan 2021 [monthly]

    Completed PHASE3

  4. Jun 2020 — Jul 2020 [monthly]

    Completed PHASE3

  5. May 2020 — Jun 2020 [monthly]

    Completed PHASE3

  6. Apr 2020 — May 2020 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  7. Feb 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  8. Dec 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  9. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE3

  10. Oct 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE3

  11. Sep 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE3

  12. Jul 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE3

  13. Jun 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE3

  14. May 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE3

  15. Jun 2018 — May 2019 [monthly]

    Active Not Recruiting PHASE3

  16. Dec 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  17. Apr 2017 — Dec 2017 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  18. Mar 2017 — Apr 2017 [monthly]

    Recruiting PHASE3

  19. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE3

  20. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Sep 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bristol-Myers Squibb
Data source: Bristol-Myers Squibb

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

A Coruña, Spain , Aachen, Germany , Albuquerque, United States , Anyang-si, South Korea , Arlington, United States , Barcelona, Spain , Berlin, Germany , Bogotá, Colombia , Bridgeport, United States , Bucharest, Romania and 160 more locations