deltatrials
Recruiting PHASE1 INTERVENTIONAL 1-arm NCT02508038

Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors

TCR-αβ+ and CD19+ Depleted KIR/KIR Ligand-mismatched Haploidentical Hematopoietic Stem Cell Transplant and Zoledronate for Pediatric Relapsed/Refractory Hematologic Malignancies and High Risk Solid Tumors

Sponsor: University of Wisconsin, Madison

Conditions Acute Lymphoblastic Leukemia Acute Myeloid Leukemia Ewing Sarcoma Hodgkin Lymphoma Myelodysplastic Syndrome Myeloproliferative Syndrome Neuroblastoma Non-Hodgkin Lymphoma Osteosarcoma Primitive Neuroectodermal Tumor Rhabdomyosarcoma
Interventions TCRαβ+/CD19+ depleted Haploidentical HSCT Zoledronate
Updated 22 times since 2017 Last updated: Oct 14, 2025 Started: Feb 12, 2016 Primary completion: Dec 31, 2026 Completion: Dec 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02508038, this PHASE1 trial focuses on Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia and remains actively recruiting participants. Sponsored by University of Wisconsin, Madison, it has been updated 22 times since 2016, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Dec 2018 · 6 months · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Apr 2019 · 3 months · monthly snapshot~Apr 2019 – ~Dec 2019 · 8 months · monthly snapshot~Dec 2019 – ~Apr 2020 · 4 months · monthly snapshot~Apr 2020 – ~Dec 2020 · 8 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Nov 2021 · 7 months · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Apr 2022 · 4 months · monthly snapshot~Apr 2022 – ~Apr 2023 · 12 months · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Dec 2023 · 6 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Nov 2025 · 11 months · monthly snapshot~Nov 2025 – present · 8 months · monthly snapshot

Change History

22 versions recorded

  1. Nov 2025 — Present [monthly]

    Recruiting PHASE1

  2. Dec 2024 — Nov 2025 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  3. Nov 2024 — Dec 2024 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  4. Sep 2024 — Nov 2024 [monthly]

    Recruiting PHASE1

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

▶ Show 17 earlier versions

  1. Dec 2023 — Jul 2024 [monthly]

    Recruiting PHASE1

  2. Jun 2023 — Dec 2023 [monthly]

    Recruiting PHASE1

  3. Apr 2023 — Jun 2023 [monthly]

    Recruiting PHASE1

  4. Apr 2022 — Apr 2023 [monthly]

    Recruiting PHASE1

  5. Dec 2021 — Apr 2022 [monthly]

    Recruiting PHASE1

  6. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  7. Apr 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  8. Jan 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  9. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  10. Apr 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  11. Dec 2019 — Apr 2020 [monthly]

    Recruiting PHASE1

  12. Apr 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  13. Jan 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  14. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

  15. Jun 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  16. Feb 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

  17. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Feb 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • University of Wisconsin, Madison
Data source: University of Wisconsin, Madison

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations