deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT02561988

(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies

A Phase 1 Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies

Sponsor: Blueprint Medicines Corporation

Interventions Avapritinib
Updated 15 times since 2017 Last updated: Mar 16, 2023 Started: Mar 10, 2016 Primary completion: Oct 5, 2022 Completion: Jan 19, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Aggressive Systemic Mastocytosis and Mast Cell Leukemia and is currently completed. Blueprint Medicines Corporation leads this study, which shows 15 recorded versions since 2016 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2018 · 13 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Jun 2019 · 10 months · monthly snapshot~Jun 2019 – ~Dec 2019 · 6 months · monthly snapshot~Dec 2019 – ~Jun 2020 · 6 months · monthly snapshot~Jun 2020 – ~Jan 2021 · 7 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Apr 2022 · 7 months · monthly snapshot~Apr 2022 – ~Feb 2023 · 10 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jul 2024 · 15 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

15 versions recorded
  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Apr 2023 — Jul 2024 [monthly]

    Completed PHASE1

  4. Feb 2023 — Apr 2023 [monthly]

    Completed PHASE1

    Status: Active Not RecruitingCompleted

  5. Apr 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1

Show 10 earlier versions
  1. Sep 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  2. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  3. Jun 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  4. Dec 2019 — Jun 2020 [monthly]

    Recruiting PHASE1

  5. Jun 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  6. Aug 2018 — Jun 2019 [monthly]

    Recruiting PHASE1

  7. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  8. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

  9. Feb 2017 — Mar 2018 [monthly]

    Recruiting PHASE1

  10. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Mar 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Blueprint Medicines Corporation
Data source: Blueprint Medicines Corporation

For direct contact, visit the study record on ClinicalTrials.gov .