deltatrials
Completed PHASE2 INTERVENTIONAL 3-arm NCT02573493

Nab-Paclitaxel and Cisplatin or Nab-paclitaxel as Induction Therapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (HNSCC) (APA)

Phase II Non-Randomized Three Arm Trial of Induction Chemotherapy With Nab-Paclitaxel and Cisplatin (AP: Arms 1 and 3) or Single Agent Nab-paclitaxel (A: Arm 2) as Induction Therapy Followed by Definitive Concurrent Chemoradiation for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (HNSCC): The APA Trial.

Sponsor: Celgene Corporation

Conditions Cancer of Head and Neck Cancer of the Head and Neck Carcinoma, Squamous Cell of the Head and Neck Head and Neck Cancer Neoplasms, Head and Neck Squamous Cell Carcinoma of the Head and Neck
Interventions Cetuximab Cisplatin Intensity-Modulated Radiation Therapy nab-Paclitaxel
Updated 27 times since 2017 Last updated: Dec 2, 2024 Started: Apr 13, 2016 Primary completion: Dec 12, 2019 Completion: Jul 1, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Cancer of Head and Neck and Cancer of the Head and Neck and is currently completed. Celgene Corporation leads this study, which shows 27 recorded versions since 2016 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Jun 2018 · 10 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Feb 2019 · 4 months · monthly snapshot~Feb 2019 – ~May 2019 · 3 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Dec 2019 · 5 months · monthly snapshot~Dec 2019 – ~Jun 2020 · 6 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Jul 2022 · 15 months · monthly snapshot~Jul 2022 – ~May 2023 · 10 months · monthly snapshot~May 2023 – ~Jun 2024 · 13 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Sep 2025 · 8 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

27 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Jan 2025 — Sep 2025 [monthly]

    Completed PHASE2

  3. Dec 2024 — Jan 2025 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  4. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 22 earlier versions

  1. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  2. May 2023 — Jun 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Jul 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE2

  4. Apr 2021 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

  5. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE2

  6. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  7. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

  8. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE2

  9. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  10. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  11. Dec 2019 — Jun 2020 [monthly]

    Recruiting PHASE2

  12. Jul 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  13. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  14. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  15. Feb 2019 — May 2019 [monthly]

    Recruiting PHASE2

  16. Oct 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  17. Aug 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  18. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  19. Aug 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  20. Jun 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  21. Feb 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  22. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Apr 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Celgene Corporation
  • Washington University School of Medicine
Data source: Washington University School of Medicine

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations