deltatrials
Recruiting OBSERVATIONAL NCT02582021

WISE CVD - Continuation (WISE HFpEF)

Women's Ischemia Syndrome Evaluation (WISE) - Coronary Microvascular Dysfunction (CMD) and Heart Failure With Preserved Ejection Fraction (HFpEF)

Sponsor: Cedars-Sinai Medical Center

Conditions Cardiovascular Disease Microvascular Coronary Dysfunction
Interventions Aortic vasorelaxation tests Cardiac Magnetic Resonance Angiography Cardiac Magnetic Resonance Imaging Computed Coronary Tomographic Angiography Coronary Angiography Coronary Reactivity Testing Rest-Stress Millar Testing
Updated 18 times since 2017 Last updated: Jul 23, 2025 Started: Nov 30, 2015 Primary completion: Feb 28, 2030 Completion: Feb 28, 2030
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02582021, this observational or N/A phase trial focuses on Cardiovascular Disease and Microvascular Coronary Dysfunction and remains actively recruiting participants. Sponsored by Cedars-Sinai Medical Center, it has been updated 18 times since 2015, reflecting substantial change activity. This study contributes longitudinal data to the cardiovascular research landscape.

Status Flow

~Jan 2017 – ~Jul 2017 · 6 months · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Apr 2018 · 8 months · monthly snapshot~Apr 2018 – ~May 2018 · 30 days · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Jan 2019 · 6 months · monthly snapshot~Jan 2019 – ~Jun 2019 · 5 months · monthly snapshot~Jun 2019 – ~Nov 2020 · 17 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Aug 2023 · 20 months · monthly snapshot~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Aug 2025 · 10 months · monthly snapshot~Aug 2025 – present · 11 months · monthly snapshot

Change History

18 versions recorded

  1. Aug 2025 — Present [monthly]

    Recruiting

  2. Oct 2024 — Aug 2025 [monthly]

    Recruiting

  3. Sep 2024 — Oct 2024 [monthly]

    Recruiting

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting

  5. Aug 2023 — Jul 2024 [monthly]

    Recruiting

▶ Show 13 earlier versions

  1. Dec 2021 — Aug 2023 [monthly]

    Recruiting

  2. Sep 2021 — Dec 2021 [monthly]

    Recruiting

  3. Jan 2021 — Sep 2021 [monthly]

    Recruiting

  4. Nov 2020 — Jan 2021 [monthly]

    Recruiting

  5. Jun 2019 — Nov 2020 [monthly]

    Recruiting

  6. Jan 2019 — Jun 2019 [monthly]

    Recruiting

  7. Jul 2018 — Jan 2019 [monthly]

    Recruiting

  8. Jun 2018 — Jul 2018 [monthly]

    Recruiting

  9. May 2018 — Jun 2018 [monthly]

    Recruiting

  10. Apr 2018 — May 2018 [monthly]

    Recruiting

    Phase: NA → None

  11. Aug 2017 — Apr 2018 [monthly]

    Recruiting NA

  12. Jul 2017 — Aug 2017 [monthly]

    Recruiting NA

  13. Jan 2017 — Jul 2017 [monthly]

    Recruiting NA

    First recorded

Nov 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Cedars-Sinai Medical Center
Data source: Cedars-Sinai Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations