deltatrials
Completed PHASE4 INTERVENTIONAL 2-arm NCT02589600

Zoledronic Acid for Osteoporotic Fracture Prevention (ZEST II) (ZEST II)

ZEST II for Osteoporotic Fracture Prevention

Sponsor: National Institute on Aging (NIA)

Conditions Osteoporosis, Postmenopausal Osteoporotic Fractures
Interventions Saline Zoledronic acid calcium vitamin D
Updated 16 times since 2017 Last updated: Sep 15, 2023 Started: Jan 31, 2016 Primary completion: Jun 22, 2022 Completion: Jun 22, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Osteoporosis, Postmenopausal and Osteoporotic Fractures and is currently completed. National Institute on Aging (NIA) leads this study, which shows 16 recorded versions since 2016 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Oct 2018 · 4 months · monthly snapshot~Oct 2018 – ~Feb 2019 · 4 months · monthly snapshot~Feb 2019 – ~Aug 2019 · 6 months · monthly snapshot~Aug 2019 – ~Jan 2020 · 5 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Jan 2021 · 11 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Feb 2022 · 12 months · monthly snapshot~Feb 2022 – ~Sep 2022 · 7 months · monthly snapshot~Sep 2022 – ~Sep 2023 · 12 months · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Jul 2024 · 9 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

16 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE4

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE4

  3. Oct 2023 — Jul 2024 [monthly]

    Completed PHASE4

  4. Sep 2023 — Oct 2023 [monthly]

    Completed PHASE4

  5. Sep 2022 — Sep 2023 [monthly]

    Completed PHASE4

    Status: Active Not Recruiting → Completed

▶ Show 11 earlier versions

  1. Feb 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE4

  2. Feb 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE4

  3. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE4

  4. Feb 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE4

  5. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE4

    Status: Recruiting → Active Not Recruiting

  6. Aug 2019 — Jan 2020 [monthly]

    Recruiting PHASE4

  7. Feb 2019 — Aug 2019 [monthly]

    Recruiting PHASE4

  8. Oct 2018 — Feb 2019 [monthly]

    Recruiting PHASE4

  9. Jun 2018 — Oct 2018 [monthly]

    Recruiting PHASE4

  10. Feb 2017 — Jun 2018 [monthly]

    Recruiting PHASE4

  11. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE4

    First recorded

Jan 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute on Aging (NIA)
  • National Institutes of Health (NIH)
  • Susan L. Greenspan
Data source: University of Pittsburgh

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations