deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 6-arm NCT02599324

Study to Evaluate Ibrutinib Combination Therapy in Patients With Selected Gastrointestinal and Genitourinary Tumors

A Phase 1b/2 Study of Ibrutinib Combination Therapy in Selected Advanced Gastrointestinal and Genitourinary Tumors

Sponsor: Pharmacyclics LLC.

Conditions Advanced Gastric Adenocarcinoma Advanced Urothelial Carcinoma Metastatic Colorectal Adenocarcinoma Metastatic Renal Cell Carcinoma
Interventions cetuximab docetaxel everolimus ibrutinib paclitaxel pembrolizumab
Updated 27 times since 2017 Last updated: Nov 14, 2023 Started: Dec 1, 2015 Primary completion: Aug 20, 2021 Completion: Aug 20, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1/PHASE2 clinical study on Advanced Gastric Adenocarcinoma and Advanced Urothelial Carcinoma, this trial is completed. The trial is conducted by Pharmacyclics LLC. and has accumulated 27 data snapshots since 2015. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~Jun 2017 · 2 months · monthly snapshot~Jun 2017 – ~Feb 2018 · 8 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Jul 2019 · 10 months · monthly snapshot~Jul 2019 – ~Jun 2020 · 11 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Oct 2021 · 8 months · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Apr 2022 · 5 months · monthly snapshot~Apr 2022 – ~Nov 2022 · 7 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Dec 2023 · 11 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

27 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1/PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  4. Dec 2023 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

  5. Jan 2023 — Dec 2023 [monthly]

    Completed PHASE1_PHASE2

▶ Show 22 earlier versions

  1. Dec 2022 — Jan 2023 [monthly]

    Completed PHASE1_PHASE2

  2. Nov 2022 — Dec 2022 [monthly]

    Completed PHASE1_PHASE2

  3. Apr 2022 — Nov 2022 [monthly]

    Completed PHASE1_PHASE2

  4. Nov 2021 — Apr 2022 [monthly]

    Completed PHASE1_PHASE2

  5. Oct 2021 — Nov 2021 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

  6. Feb 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  7. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1_PHASE2

  8. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  9. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1_PHASE2

  10. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1_PHASE2

  11. Aug 2020 — Oct 2020 [monthly]

    Recruiting PHASE1_PHASE2

  12. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1_PHASE2

  13. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1_PHASE2

  14. Jul 2019 — Jun 2020 [monthly]

    Recruiting PHASE1_PHASE2

  15. Sep 2018 — Jul 2019 [monthly]

    Recruiting PHASE1_PHASE2

  16. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE1_PHASE2

  17. Feb 2018 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  18. Jun 2017 — Feb 2018 [monthly]

    Recruiting PHASE1_PHASE2

  19. Apr 2017 — Jun 2017 [monthly]

    Recruiting PHASE1_PHASE2

  20. Mar 2017 — Apr 2017 [monthly]

    Recruiting PHASE1_PHASE2

  21. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE1_PHASE2

  22. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Dec 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Pharmacyclics LLC.
Data source: Pharmacyclics LLC.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albuquerque, United States , Badalona, Spain , Barcelona, Spain , Berkeley, United States , Bolivar, United States , Boston, United States , Brick, United States , Columbus, United States , Daly City, United States , Detroit, United States and 44 more locations