deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT02603146

Strategy to Prevent the Onset of Clinically-Apparent Rheumatoid Arthritis (StopRA)

Sponsor: Autoimmunity Centers of Excellence

Conditions Healthy Participants Rheumatoid Arthritis (RA) Prevention
Interventions HCQ Placebo Hydroxychloroquine
Updated 34 times since 2017 Last updated: May 27, 2025 Started: Apr 27, 2016 Primary completion: Nov 1, 2022 Completion: Nov 1, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Enrollment was closed before reaching the target. In the 1st interim analysis after enrollment closure, the follow up \& treatment of active participants were stopped early due to evidence of futility.

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A PHASE2 clinical study on Healthy Participants and Rheumatoid Arthritis (RA) Prevention, this trial is terminated or withdrawn. The trial is conducted by Autoimmunity Centers of Excellence and has accumulated 34 data snapshots since 2016. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Aug 2017 · 6 months · monthly snapshot~Aug 2017 – ~Jun 2018 · 10 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Apr 2019 · 3 months · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jan 2021 · 8 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Dec 2021 · 6 months · monthly snapshot~Dec 2021 – ~Jun 2022 · 6 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~May 2023 · 4 months · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Dec 2023 · 4 months · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Jul 2024 · 6 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshot~Jul 2025 – present · 12 months · monthly snapshot

Change History

34 versions recorded

  1. Jul 2025 — Present [monthly]

    Terminated PHASE2

  2. Sep 2024 — Jul 2025 [monthly]

    Terminated PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  4. Jan 2024 — Jul 2024 [monthly]

    Terminated PHASE2

  5. Dec 2023 — Jan 2024 [monthly]

    Terminated PHASE2

    Status: Completed → Terminated

▶ Show 29 earlier versions

  1. Aug 2023 — Dec 2023 [monthly]

    Completed PHASE2

  2. May 2023 — Aug 2023 [monthly]

    Completed PHASE2

  3. Jan 2023 — May 2023 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  4. Sep 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE2

  5. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  6. Dec 2021 — Jun 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  7. Jun 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  8. Apr 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  9. Feb 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  10. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  11. May 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  12. Mar 2020 — May 2020 [monthly]

    Recruiting PHASE2

  13. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  14. Nov 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  15. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  16. Aug 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  17. Jun 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  18. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  19. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  20. Jan 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  21. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  22. Oct 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  23. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  24. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  25. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  26. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  27. Aug 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  28. Feb 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  29. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Apr 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Autoimmunity Centers of Excellence
  • National Institute of Allergy and Infectious Diseases (NIAID)
Data source: National Institute of Allergy and Infectious Diseases (NIAID)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Ann Arbor, United States , Atlanta, United States , Aurora, United States , Birmingham, United States , Boston, United States , Dallas, United States , Great Neck, United States , Los Angeles, United States , Oklahoma City, United States , Omaha, United States and 3 more locations