deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT02644291

Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Conditions Anaplastic Astrocytoma Anaplastic Oligodendroglioma Astrocytoma, Grade III Brain Stem Neoplasms, Malignant Glioblastoma Malignant Glioma Medulloblastoma Oligodendroblastoma
Interventions Mebendazole
Updated 13 times since 2017 Last updated: Jun 16, 2022 Started: May 31, 2016 Primary completion: Jun 9, 2022 Completion: Jun 9, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Anaplastic Astrocytoma and Anaplastic Oligodendroglioma, this trial is completed. The trial is conducted by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and has accumulated 13 data snapshots since 2016. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Jun 2018 · 12 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Oct 2019 · 13 months · monthly snapshot~Oct 2019 – ~Oct 2020 · 12 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Jul 2022 · 9 months · monthly snapshot~Jul 2022 – ~Jul 2024 · 24 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 8 months · monthly snapshot

Change History

13 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  4. Jul 2022 — Jul 2024 [monthly]

    Completed PHASE1

    Status: Recruiting → Completed

  5. Oct 2021 — Jul 2022 [monthly]

    Recruiting PHASE1

▶ Show 8 earlier versions

  1. Jan 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  2. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  3. Oct 2019 — Oct 2020 [monthly]

    Recruiting PHASE1

  4. Sep 2018 — Oct 2019 [monthly]

    Recruiting PHASE1

  5. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  6. Jun 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

  7. Feb 2017 — Jun 2017 [monthly]

    Recruiting PHASE1

  8. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

May 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Data source: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations