Not Yet Recruiting PHASE1_PHASE2 Interventional 2-arm NCT02670889

Urease Inhibitor Drug Treatment for Urea Cycle Disorders

Manipulating the Gut Microbiome in Urea Cycle Disorders

Sponsor: Children's Hospital of Philadelphia

Conditions Argininosuccinate Synthetase Deficiency (Citrullinemia) Argininosuccinic Acid Lyase Deficiency (Argininosuccinic Aciduria) Carbamyl-Phosphate Synthase I Deficiency Ornithine Transcarbamylase Deficiency

Interventions Acetohydroxamic Acid Isotopic Intravenous [13C]-Urea

Updated 3 times since 2017 Last updated: Aug 23, 2016

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1_PHASE2 clinical study on Argininosuccinate Synthetase Deficiency (Citrullinemia) and Argininosuccinic Acid Lyase Deficiency (Argininosuccinic Aciduria), this trial is actively recruiting participants. The trial is conducted by Children's Hospital of Philadelphia and has accumulated 3 data snapshots since 2026. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

3 versions recorded

Jun 2018 — Present [monthly]

Not Yet Recruiting PHASE1_PHASE2
Feb 2017 — Jun 2018 [monthly]

Not Yet Recruiting PHASE1_PHASE2
Jan 2017 — Feb 2017 [monthly]

Not Yet Recruiting PHASE1_PHASE2

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Children's Hospital of Philadelphia
Data Management and Coordinating Center (DMCC)
Nicholas Ah Mew

Data source: Children's Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

No location information available.