deltatrials
Active Not Recruiting NA INTERVENTIONAL 2-arm NCT02675114

PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis (P3)

A Prospective, Randomized, Controlled, Multi-Center Study to Establish the Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients Who Have Severe, Calcific, Aortic Stenosis Requiring Aortic Valve Replacement

Sponsor: Edwards Lifesciences

Conditions Aortic Stenosis
Interventions SAPIEN 3 THV SAVR
Updated 29 times since 2017 Last updated: Dec 19, 2025 Started: Mar 31, 2016 Primary completion: Nov 16, 2020 Completion: Dec 31, 2029
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02675114, this NA trial focuses on Aortic Stenosis and remains ongoing. Sponsored by Edwards Lifesciences, it has been updated 29 times since 2016, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~Jul 2017 · 3 months · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Jun 2018 · 9 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Feb 2020 · 5 months · monthly snapshot~Feb 2020 – ~Jun 2020 · 4 months · monthly snapshot~Jun 2020 – ~Jan 2021 · 7 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Jan 2022 · 8 months · monthly snapshot~Jan 2022 – ~Dec 2022 · 11 months · monthly snapshot~Dec 2022 – ~Dec 2023 · 12 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Sep 2025 · 9 months · monthly snapshot~Sep 2025 – ~Feb 2026 · 5 months · monthly snapshot~Feb 2026 – present · 6 months · monthly snapshot

Change History

29 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting NA

  2. Sep 2025 — Feb 2026 [monthly]

    Active Not Recruiting NA

  3. Dec 2024 — Sep 2025 [monthly]

    Active Not Recruiting NA

  4. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting NA

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting NA

▶ Show 24 earlier versions

  1. Dec 2023 — Jul 2024 [monthly]

    Active Not Recruiting NA

  2. Dec 2022 — Dec 2023 [monthly]

    Active Not Recruiting NA

  3. Jan 2022 — Dec 2022 [monthly]

    Active Not Recruiting NA

  4. May 2021 — Jan 2022 [monthly]

    Active Not Recruiting NA

  5. Jan 2021 — May 2021 [monthly]

    Active Not Recruiting NA

  6. Jun 2020 — Jan 2021 [monthly]

    Active Not Recruiting NA

    Status: Recruiting → Active Not Recruiting

  7. Feb 2020 — Jun 2020 [monthly]

    Recruiting NA

  8. Sep 2019 — Feb 2020 [monthly]

    Recruiting NA

  9. Aug 2019 — Sep 2019 [monthly]

    Recruiting NA

  10. Jul 2019 — Aug 2019 [monthly]

    Recruiting NA

  11. May 2019 — Jul 2019 [monthly]

    Recruiting NA

  12. Mar 2019 — May 2019 [monthly]

    Recruiting NA

  13. Jan 2019 — Mar 2019 [monthly]

    Recruiting NA

  14. Dec 2018 — Jan 2019 [monthly]

    Recruiting NA

  15. Nov 2018 — Dec 2018 [monthly]

    Recruiting NA

  16. Sep 2018 — Nov 2018 [monthly]

    Recruiting NA

  17. Jun 2018 — Sep 2018 [monthly]

    Recruiting NA

  18. Sep 2017 — Jun 2018 [monthly]

    Recruiting NA

    Phase: PHASE3 → NA

  19. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE3

  20. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE3

  21. Apr 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

  22. Mar 2017 — Apr 2017 [monthly]

    Recruiting PHASE3

  23. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE3

  24. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Mar 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Edwards Lifesciences
Data source: Edwards Lifesciences

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Adelaide, Australia , Albany, United States , Atlanta, United States , Atlantis, United States , Auburn, United States , Austin, United States , Bedford Park, Australia , Birmingham, United States , Boston, United States , Buffalo, United States and 61 more locations