deltatrials
Recruiting PHASE2 INTERVENTIONAL 2-arm NCT02691923

Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker

Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker: Correlation With Preoperative MR, ALA-induced PpIX Fluorescence, and Histopathology

Sponsor: Carl Zeiss Meditec, Inc.

Conditions Brain Cancer
Interventions Fluorescein Fluorescein + ALA
Updated 14 times since 2017 Last updated: Jul 30, 2025 Started: Mar 31, 2016 Primary completion: Dec 31, 2025 Completion: Dec 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02691923, this PHASE2 trial focuses on Brain Cancer and remains actively recruiting participants. Sponsored by Carl Zeiss Meditec, Inc., it has been updated 14 times since 2016, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2018 · 14 months · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Jul 2019 · 11 months · monthly snapshot~Jul 2019 – ~Aug 2020 · 13 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Sep 2022 · 12 months · monthly snapshot~Sep 2022 – ~Jun 2023 · 9 months · monthly snapshot~Jun 2023 – ~Jul 2024 · 13 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

14 versions recorded

  1. Sep 2025 — Present [monthly]

    Recruiting PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Recruiting PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  4. Jun 2023 — Jul 2024 [monthly]

    Recruiting PHASE2

  5. Sep 2022 — Jun 2023 [monthly]

    Recruiting PHASE2

▶ Show 9 earlier versions

  1. Sep 2021 — Sep 2022 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

  2. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  3. Aug 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Jul 2019 — Aug 2020 [monthly]

    Recruiting PHASE2

  5. Aug 2018 — Jul 2019 [monthly]

    Recruiting PHASE2

  6. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  7. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  8. Feb 2017 — Apr 2018 [monthly]

    Recruiting PHASE2

  9. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Mar 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Carl Zeiss Meditec, Inc.
  • David W. Roberts
  • National Institute of Neurological Disorders and Stroke (NINDS)
Data source: Dartmouth-Hitchcock Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations