deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT02697630

Efficacy Study of Pembrolizumab With Entinostat to Treat Metastatic Melanoma of the Eye (PEMDAC)

A Multicenter Phase II Open Label Study to Evaluate Efficacy of Concomitant Use of Pembrolizumab and Entinostat in Adult Patients With Metastatic Uveal Melanoma

Sponsor: Merck Sharp & Dohme LLC

Updated 13 times since 2017 Last updated: Dec 1, 2023 Started: Feb 21, 2018 Primary completion: Jan 31, 2023 Completion: Jan 31, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Metastatic Uveal Melanoma and is currently completed. Merck Sharp & Dohme LLC leads this study, which shows 13 recorded versions since 2018 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Jun 2017 · 5 months · monthly snapshot~Jun 2017 – ~Feb 2018 · 8 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Feb 2019 · 8 months · monthly snapshot~Feb 2019 – ~Nov 2019 · 9 months · monthly snapshot~Nov 2019 – ~Jan 2021 · 14 months · monthly snapshot~Jan 2021 – ~Jun 2022 · 17 months · monthly snapshot~Jun 2022 – ~Sep 2023 · 15 months · monthly snapshot~Sep 2023 – ~Jan 2024 · 4 months · monthly snapshot~Jan 2024 – ~Jul 2024 · 6 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

13 versions recorded
  1. Sep 2024 — Present [monthly]

    Completed PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  3. Jan 2024 — Jul 2024 [monthly]

    Completed PHASE2

    Status: Unknown StatusCompleted

  4. Sep 2023 — Jan 2024 [monthly]

    Unknown Status PHASE2

    Status: Active Not RecruitingUnknown Status

  5. Jun 2022 — Sep 2023 [monthly]

    Active Not Recruiting PHASE2

Show 8 earlier versions
  1. Jan 2021 — Jun 2022 [monthly]

    Active Not Recruiting PHASE2

  2. Nov 2019 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  3. Feb 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  4. Jun 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  5. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  6. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  7. Jun 2017 — Feb 2018 [monthly]

    Not Yet Recruiting PHASE2

  8. Jan 2017 — Jun 2017 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Merck Sharp & Dohme LLC
  • Syndax Pharmaceuticals
  • Vastra Gotaland Region
Data source: Vastra Gotaland Region

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations